Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina

We investigated the role of glutathione S-transferase (GST) enzymes (M1, T1), methylenetetrahydrofolate (MTHFR) 677 and 1298, and the NAD(P)H:quinone oxidoreductase (NQO1) polymorphisms in a population-based bladder cancer case-control study in Argentina. Buccal cell DNA was obtained from 106 cases...

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Autores principales: Moore, Lee E., Wiencke, John, Bates, Michael N., Zheng, Schichun, Rey, Omar C., Smith, Allan H.
Formato: Artículo
Lenguaje:Español
Publicado: 2004
Materias:
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3978/1/A_Moore_Wiencke_Bates_Zheng_Rey_Smith.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3978
record_format dspace
spelling I38-R144-39782025-04-11T18:45:15Z http://pa.bibdigital.ucc.edu.ar/3978/ Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina Moore, Lee E. Wiencke, John Bates, Michael N. Zheng, Schichun Rey, Omar C. Smith, Allan H. R Medicina (General) We investigated the role of glutathione S-transferase (GST) enzymes (M1, T1), methylenetetrahydrofolate (MTHFR) 677 and 1298, and the NAD(P)H:quinone oxidoreductase (NQO1) polymorphisms in a population-based bladder cancer case-control study in Argentina. Buccal cell DNA was obtained from 106 cases and 109 controls. The strongest evidence was for an interaction between NQO1 genotype and smoking. For ever smoking vs. never smoking the odds ratio was 8.6 (95% confidence interval (CI) 2.7-27), in the CC genotype, and 1.3 (95% CI 0.5-3.5) in the CT and TT genotypes combined. Also, elevated bladder cancer risks associated with GSTM1 and GSTT1 null genotypes were found in smokers. Having both null polymorphisms conferred the highest risks. The MTHFR 677 CT and TT polymorphisms appeared protective against bladder cancer. 2004-08-10 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/3978/1/A_Moore_Wiencke_Bates_Zheng_Rey_Smith.pdf Moore, Lee E., Wiencke, John ORCID: https://orcid.org/0000-0001-7101-6489 <https://orcid.org/0000-0001-7101-6489>, Bates, Michael N., Zheng, Schichun, Rey, Omar C. ORCID: https://orcid.org/0000-0002-9232-1252 <https://orcid.org/0000-0002-9232-1252> and Smith, Allan H. (2004) Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina. Cancer Letters, 211 (2). pp. 199-207. ISSN 0304-3835 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.canlet.2004.04.011
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
spellingShingle R Medicina (General)
Moore, Lee E.
Wiencke, John
Bates, Michael N.
Zheng, Schichun
Rey, Omar C.
Smith, Allan H.
Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina
topic_facet R Medicina (General)
description We investigated the role of glutathione S-transferase (GST) enzymes (M1, T1), methylenetetrahydrofolate (MTHFR) 677 and 1298, and the NAD(P)H:quinone oxidoreductase (NQO1) polymorphisms in a population-based bladder cancer case-control study in Argentina. Buccal cell DNA was obtained from 106 cases and 109 controls. The strongest evidence was for an interaction between NQO1 genotype and smoking. For ever smoking vs. never smoking the odds ratio was 8.6 (95% confidence interval (CI) 2.7-27), in the CC genotype, and 1.3 (95% CI 0.5-3.5) in the CT and TT genotypes combined. Also, elevated bladder cancer risks associated with GSTM1 and GSTT1 null genotypes were found in smokers. Having both null polymorphisms conferred the highest risks. The MTHFR 677 CT and TT polymorphisms appeared protective against bladder cancer.
format Artículo
author Moore, Lee E.
Wiencke, John
Bates, Michael N.
Zheng, Schichun
Rey, Omar C.
Smith, Allan H.
author_facet Moore, Lee E.
Wiencke, John
Bates, Michael N.
Zheng, Schichun
Rey, Omar C.
Smith, Allan H.
author_sort Moore, Lee E.
title Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina
title_short Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina
title_full Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina
title_fullStr Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina
title_full_unstemmed Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina
title_sort investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in argentina
publishDate 2004
url http://pa.bibdigital.ucc.edu.ar/3978/1/A_Moore_Wiencke_Bates_Zheng_Rey_Smith.pdf
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AT zhengschichun investigationofgeneticpolymorphismsandsmokinginabladdercancercasecontrolstudyinargentina
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