Hepatitis C virus genotypes in Cordoba, Argentina. Unexpected high prevalence of genotype 2

To determine hepatitis C virus (HCV) genotypes circulating in the central region of Argentina, 96 consecutive anti-HCV positive subjects were studied. The presence of HCV RNA was detected in 60 samples by RT-nested PCR of the 5′ noncoding region (5′ NCR). Genotyping was performed by restriction frag...

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Autores principales: Re, Viviana Elizabeth, Lampe, Elisabeth, Yoshida, Clara Fumiko, De Oliveira, Jaqueline Mendes, Lewis Ximenez, Lia, Spinsanti, Lorena, Elbarcha, Osvaldo César, Contigiani, Marta Silvia
Formato: Artículo
Lenguaje:Español
Publicado: Instituto de Investigaciones Medicas 2003
Materias:
QD Química
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3965/1/A_Re_Lampe_Yoshida_DeOliveira_LewisXimenez_Spinsanti_Elbarcha_Contigiani.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3965
record_format dspace
spelling I38-R144-39652025-04-11T22:21:19Z http://pa.bibdigital.ucc.edu.ar/3965/ Hepatitis C virus genotypes in Cordoba, Argentina. Unexpected high prevalence of genotype 2 Re, Viviana Elizabeth Lampe, Elisabeth Yoshida, Clara Fumiko De Oliveira, Jaqueline Mendes Lewis Ximenez, Lia Spinsanti, Lorena Elbarcha, Osvaldo César Contigiani, Marta Silvia QD Química To determine hepatitis C virus (HCV) genotypes circulating in the central region of Argentina, 96 consecutive anti-HCV positive subjects were studied. The presence of HCV RNA was detected in 60 samples by RT-nested PCR of the 5′ noncoding region (5′ NCR). Genotyping was performed by restriction fragment length polymorphism analysis of 5′ NCR region combined with PCR using type-specific primers of the core region. The groups of individuals in this study included hemophilia and hemodialysis patients, injecting drug users, screened blood donors, and patients with acute or chronic liver disease, all from Córdoba, Argentina. Overall, genotype 2 was the most prevalent (55.0%), followed by genotypes 1 (38.3%), and 3 (5.0%). Within genotype 1, subtype 1b was the most prevalent. An unexpected high prevalence of genotype 2 (61.9%) was found among patients with acute or chronic HCV infection (without known risk factors). These figures differ from other cohorts from East-Argentina where genotype 1 has been found as the most prevalent. This indicates that regional differences of genotype distribution might exist between Central and East Argentina. Instituto de Investigaciones Medicas 2003-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/3965/1/A_Re_Lampe_Yoshida_DeOliveira_LewisXimenez_Spinsanti_Elbarcha_Contigiani.pdf Re, Viviana Elizabeth ORCID: https://orcid.org/0000-0002-4106-6642 <https://orcid.org/0000-0002-4106-6642>, Lampe, Elisabeth, Yoshida, Clara Fumiko, De Oliveira, Jaqueline Mendes, Lewis Ximenez, Lia, Spinsanti, Lorena ORCID: https://orcid.org/0000-0002-0157-4570 <https://orcid.org/0000-0002-0157-4570>, Elbarcha, Osvaldo César and Contigiani, Marta Silvia ORCID: https://orcid.org/0000-0002-7171-0013 <https://orcid.org/0000-0002-7171-0013> (2003) Hepatitis C virus genotypes in Cordoba, Argentina. Unexpected high prevalence of genotype 2. Medicina (Argentina), 63 (3). pp. 205-210. ISSN 0025-7680
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic QD Química
spellingShingle QD Química
Re, Viviana Elizabeth
Lampe, Elisabeth
Yoshida, Clara Fumiko
De Oliveira, Jaqueline Mendes
Lewis Ximenez, Lia
Spinsanti, Lorena
Elbarcha, Osvaldo César
Contigiani, Marta Silvia
Hepatitis C virus genotypes in Cordoba, Argentina. Unexpected high prevalence of genotype 2
topic_facet QD Química
description To determine hepatitis C virus (HCV) genotypes circulating in the central region of Argentina, 96 consecutive anti-HCV positive subjects were studied. The presence of HCV RNA was detected in 60 samples by RT-nested PCR of the 5′ noncoding region (5′ NCR). Genotyping was performed by restriction fragment length polymorphism analysis of 5′ NCR region combined with PCR using type-specific primers of the core region. The groups of individuals in this study included hemophilia and hemodialysis patients, injecting drug users, screened blood donors, and patients with acute or chronic liver disease, all from Córdoba, Argentina. Overall, genotype 2 was the most prevalent (55.0%), followed by genotypes 1 (38.3%), and 3 (5.0%). Within genotype 1, subtype 1b was the most prevalent. An unexpected high prevalence of genotype 2 (61.9%) was found among patients with acute or chronic HCV infection (without known risk factors). These figures differ from other cohorts from East-Argentina where genotype 1 has been found as the most prevalent. This indicates that regional differences of genotype distribution might exist between Central and East Argentina.
format Artículo
author Re, Viviana Elizabeth
Lampe, Elisabeth
Yoshida, Clara Fumiko
De Oliveira, Jaqueline Mendes
Lewis Ximenez, Lia
Spinsanti, Lorena
Elbarcha, Osvaldo César
Contigiani, Marta Silvia
author_facet Re, Viviana Elizabeth
Lampe, Elisabeth
Yoshida, Clara Fumiko
De Oliveira, Jaqueline Mendes
Lewis Ximenez, Lia
Spinsanti, Lorena
Elbarcha, Osvaldo César
Contigiani, Marta Silvia
author_sort Re, Viviana Elizabeth
title Hepatitis C virus genotypes in Cordoba, Argentina. Unexpected high prevalence of genotype 2
title_short Hepatitis C virus genotypes in Cordoba, Argentina. Unexpected high prevalence of genotype 2
title_full Hepatitis C virus genotypes in Cordoba, Argentina. Unexpected high prevalence of genotype 2
title_fullStr Hepatitis C virus genotypes in Cordoba, Argentina. Unexpected high prevalence of genotype 2
title_full_unstemmed Hepatitis C virus genotypes in Cordoba, Argentina. Unexpected high prevalence of genotype 2
title_sort hepatitis c virus genotypes in cordoba, argentina. unexpected high prevalence of genotype 2
publisher Instituto de Investigaciones Medicas
publishDate 2003
url http://pa.bibdigital.ucc.edu.ar/3965/1/A_Re_Lampe_Yoshida_DeOliveira_LewisXimenez_Spinsanti_Elbarcha_Contigiani.pdf
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