The spectrum of renal osteodystrophy in Argentina [Espectro bioquímico e histológico de la osteodistrofia renal en Argentina]
Between 1994-2001 we have performed 57 bone biopsies for diagnostic purposes in symptomatic CRF patients. We analyzed here 52 samples where the material was optimal for study, and divided them into 2 periods according to when the biopsy was performed: 1994-1996 and 1997-2001, to verify changes in th...
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2003
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| Acceso en línea: | http://pa.bibdigital.ucc.edu.ar/3953/1/A_Douthat_Garay_DeArteaga_Fern%C3%A1ndezMart%C3%ADn_CannataAnd%C3%ADa_Massari.pdf |
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I38-R144-39532025-04-09T22:05:38Z http://pa.bibdigital.ucc.edu.ar/3953/ The spectrum of renal osteodystrophy in Argentina [Espectro bioquímico e histológico de la osteodistrofia renal en Argentina] Douthat, Walter Guillermo Garay, Gabriela De Arteaga, Javier Fernández Martín, J.L. Cannata Andía, J.B. Massari, Pablo U. R Medicina (General) Between 1994-2001 we have performed 57 bone biopsies for diagnostic purposes in symptomatic CRF patients. We analyzed here 52 samples where the material was optimal for study, and divided them into 2 periods according to when the biopsy was performed: 1994-1996 and 1997-2001, to verify changes in the spectrum of renal osteodystrophy. Mean serum values were: serum calcium 9.9 ± 1.8 mg/dl, phosphate 5.8 ± 3.2 mg/dl, alkaline phosphatase 693.9 ± 968.9 UI/L, iPTH 562.0 ± 598.5 pg/ml, serum aluminum 65.7 ± 79.3 ug/L and bone aluminum 22.8 ± 22.4 ug/g. Hyperparathyroidism was the most common histological diagnosis as severe in 13 patients (25%), or as mild in 14 (27%). Ten patients had osteomalacia (19%), adynamic bone disease was diagnosed in 5 (9.6%) and mixed renal osteodystrophy in 10 (19.2%). Low bone turnover patients showed higher bone and serum aluminum than high bone turnover patients. We observed a relative increment in high turnover bone disease in the later period (1997-2001) without changes in low turnover bone disease. These data showed a high prevalence of hyperparathyroidism and aluminumrelated low turnover bone disease, with no significant changes between the two time-periods analyzed here. 2003-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/3953/1/A_Douthat_Garay_DeArteaga_Fern%C3%A1ndezMart%C3%ADn_CannataAnd%C3%ADa_Massari.pdf Douthat, Walter Guillermo ORCID: https://orcid.org/0000-0002-4644-6003 <https://orcid.org/0000-0002-4644-6003>, Garay, Gabriela, De Arteaga, Javier, Fernández Martín, J.L., Cannata Andía, J.B. ORCID: https://orcid.org/0000-0001-6543-9960 <https://orcid.org/0000-0001-6543-9960> and Massari, Pablo U. (2003) The spectrum of renal osteodystrophy in Argentina [Espectro bioquímico e histológico de la osteodistrofia renal en Argentina]. Nefrologia, 23 (2). pp. 47-51. ISSN 0211-6995 |
| institution |
Universidad Católica de Córdoba |
| institution_str |
I-38 |
| repository_str |
R-144 |
| collection |
Producción Académica Universidad Católica de Córdoba (UCCor) |
| language |
Español |
| orig_language_str_mv |
spa |
| topic |
R Medicina (General) |
| spellingShingle |
R Medicina (General) Douthat, Walter Guillermo Garay, Gabriela De Arteaga, Javier Fernández Martín, J.L. Cannata Andía, J.B. Massari, Pablo U. The spectrum of renal osteodystrophy in Argentina [Espectro bioquímico e histológico de la osteodistrofia renal en Argentina] |
| topic_facet |
R Medicina (General) |
| description |
Between 1994-2001 we have performed 57 bone biopsies for diagnostic purposes in symptomatic CRF patients. We analyzed here 52 samples where the material was optimal for study, and divided them into 2 periods according to when the biopsy was performed: 1994-1996 and 1997-2001, to verify changes in the spectrum of renal osteodystrophy. Mean serum values were: serum calcium 9.9 ± 1.8 mg/dl, phosphate 5.8 ± 3.2 mg/dl, alkaline phosphatase 693.9 ± 968.9 UI/L, iPTH 562.0 ± 598.5 pg/ml, serum aluminum 65.7 ± 79.3 ug/L and bone aluminum 22.8 ± 22.4 ug/g. Hyperparathyroidism was the most common histological diagnosis as severe in 13 patients (25%), or as mild in 14 (27%). Ten patients had osteomalacia (19%), adynamic bone disease was diagnosed in 5 (9.6%) and mixed renal osteodystrophy in 10 (19.2%). Low bone turnover patients showed higher bone and serum aluminum than high bone turnover patients. We observed a relative increment in high turnover bone disease in the later period (1997-2001) without changes in low turnover bone disease. These data showed a high prevalence of hyperparathyroidism and aluminumrelated low turnover bone disease, with no significant changes between the two time-periods analyzed here. |
| format |
Artículo |
| author |
Douthat, Walter Guillermo Garay, Gabriela De Arteaga, Javier Fernández Martín, J.L. Cannata Andía, J.B. Massari, Pablo U. |
| author_facet |
Douthat, Walter Guillermo Garay, Gabriela De Arteaga, Javier Fernández Martín, J.L. Cannata Andía, J.B. Massari, Pablo U. |
| author_sort |
Douthat, Walter Guillermo |
| title |
The spectrum of renal osteodystrophy in Argentina
[Espectro bioquímico e histológico de la osteodistrofia renal en Argentina] |
| title_short |
The spectrum of renal osteodystrophy in Argentina
[Espectro bioquímico e histológico de la osteodistrofia renal en Argentina] |
| title_full |
The spectrum of renal osteodystrophy in Argentina
[Espectro bioquímico e histológico de la osteodistrofia renal en Argentina] |
| title_fullStr |
The spectrum of renal osteodystrophy in Argentina
[Espectro bioquímico e histológico de la osteodistrofia renal en Argentina] |
| title_full_unstemmed |
The spectrum of renal osteodystrophy in Argentina
[Espectro bioquímico e histológico de la osteodistrofia renal en Argentina] |
| title_sort |
spectrum of renal osteodystrophy in argentina
[espectro bioquímico e histológico de la osteodistrofia renal en argentina] |
| publishDate |
2003 |
| url |
http://pa.bibdigital.ucc.edu.ar/3953/1/A_Douthat_Garay_DeArteaga_Fern%C3%A1ndezMart%C3%ADn_CannataAnd%C3%ADa_Massari.pdf |
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