Neutralizing response elicited by homologous and heterologous prime booster vaccination against ancestral SARS-CoV-2 B.1, P.1, C.37 and B.1.617.2 variants

Heterologous Covid-19 vaccination strategies arose due to interruption of vaccination programs plus delay and shortage of vaccine supplies. We analysed neutralizing response against ancestral SARS-CoV-2 B.1 and P.1, C.37 and B.1.67.2 variants elicited by 16 homologous and heterologous protocols comb...

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Detalles Bibliográficos
Autores principales: Blanco, Sebastián, Spinsanti, Lorena, Aguilar, Juan Javier, Diaz, Adrián, Beranek, Mauricio, Fernández, Elmer Andrés, Mangeaud, Arnaldo Pedro, Konigheim, Brenda Salomé, Gallego, Sandra Verónica
Formato: Artículo
Lenguaje:Español
Publicado: Elsevier Ltd 2022
Materias:
R Medicina (General)
RB Patología
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3507/1/A_Blanco_Spinsanti_Aguilar.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3507
record_format dspace
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
RB Patología
spellingShingle R Medicina (General)
RB Patología
Blanco, Sebastián
Spinsanti, Lorena
Aguilar, Juan Javier
Diaz, Adrián
Beranek, Mauricio
Fernández, Elmer Andrés
Mangeaud, Arnaldo Pedro
Konigheim, Brenda Salomé
Gallego, Sandra Verónica
Neutralizing response elicited by homologous and heterologous prime booster vaccination against ancestral SARS-CoV-2 B.1, P.1, C.37 and B.1.617.2 variants
topic_facet R Medicina (General)
RB Patología
description Heterologous Covid-19 vaccination strategies arose due to interruption of vaccination programs plus delay and shortage of vaccine supplies. We analysed neutralizing response against ancestral SARS-CoV-2 B.1 and P.1, C.37 and B.1.67.2 variants elicited by 16 homologous and heterologous protocols combining Gam-COVID-Vac, ChAdOx1-S, Ad5-nCorV, BBIBP-CorV and mRNA-1273 vaccines. Homologous mRNA-1273 and heterologous schemes of a non-replicative viral vector/inactivated virus-based vaccine combined with mRNA-1273 induced significantly broader and greater neutralizing antibody-response. Moreover, serum from participants vaccinated with combinations of ChAdOx1-S/Ad5-nCorV and BBIBP-CorV/non-replicative viral vector-based vaccines showed higher or equivalent neutralizing response compared to homologous protocols, pointing them as good alternative platforms. BBIBP-CorV used as second dose exhibited significantly lower neutralizing response compared to other protocols, demonstrating that it should not be recommended as second dose. The information provided herein is valuable to redesign vaccination strategies, especially for low-income countries that still struggle with low percentages of immunized populations and vaccine supply shortage.
format Artículo
Artículo
author Blanco, Sebastián
Spinsanti, Lorena
Aguilar, Juan Javier
Diaz, Adrián
Beranek, Mauricio
Fernández, Elmer Andrés
Mangeaud, Arnaldo Pedro
Konigheim, Brenda Salomé
Gallego, Sandra Verónica
author_facet Blanco, Sebastián
Spinsanti, Lorena
Aguilar, Juan Javier
Diaz, Adrián
Beranek, Mauricio
Fernández, Elmer Andrés
Mangeaud, Arnaldo Pedro
Konigheim, Brenda Salomé
Gallego, Sandra Verónica
author_sort Blanco, Sebastián
title Neutralizing response elicited by homologous and heterologous prime booster vaccination against ancestral SARS-CoV-2 B.1, P.1, C.37 and B.1.617.2 variants
title_short Neutralizing response elicited by homologous and heterologous prime booster vaccination against ancestral SARS-CoV-2 B.1, P.1, C.37 and B.1.617.2 variants
title_full Neutralizing response elicited by homologous and heterologous prime booster vaccination against ancestral SARS-CoV-2 B.1, P.1, C.37 and B.1.617.2 variants
title_fullStr Neutralizing response elicited by homologous and heterologous prime booster vaccination against ancestral SARS-CoV-2 B.1, P.1, C.37 and B.1.617.2 variants
title_full_unstemmed Neutralizing response elicited by homologous and heterologous prime booster vaccination against ancestral SARS-CoV-2 B.1, P.1, C.37 and B.1.617.2 variants
title_sort neutralizing response elicited by homologous and heterologous prime booster vaccination against ancestral sars-cov-2 b.1, p.1, c.37 and b.1.617.2 variants
publisher Elsevier Ltd
publishDate 2022
url http://pa.bibdigital.ucc.edu.ar/3507/1/A_Blanco_Spinsanti_Aguilar.pdf
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