Active smoking effect in allergic rhinitis

Background: Tobacco smoke has been described as causing increased prevalence of rhinitis symptoms and decreased atopy. Furthermore, these nasal symptoms and quality of life in smokers with Allergic Rhinitis (AR) were not significantly different to non-smokers. As a result of this duality, a comparis...

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Detalles Bibliográficos
Autores principales: Gómez, René Maximiliano, Croce, Víctor Hugo, Zernotti, Mario Emilio, Muiño, Juan Carlos
Formato: Artículo
Lenguaje:Español
Publicado: Elsevier Inc. 2021
Materias:
R Medicina (General)
RF Otorrinolaringología
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3467/1/A_Gomez_Croce_Zernotti.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3467
record_format dspace
spelling I38-R144-34672025-04-10T18:35:50Z http://pa.bibdigital.ucc.edu.ar/3467/ Active smoking effect in allergic rhinitis Gómez, René Maximiliano Croce, Víctor Hugo Zernotti, Mario Emilio Muiño, Juan Carlos R Medicina (General) RF Otorrinolaringología Background: Tobacco smoke has been described as causing increased prevalence of rhinitis symptoms and decreased atopy. Furthermore, these nasal symptoms and quality of life in smokers with Allergic Rhinitis (AR) were not significantly different to non-smokers. As a result of this duality, a comparison study between the quality of life and inflammatory markers of atopy among active smokers and non-smokers having AR was put forward. Material and methods: Cross-sectional study in adult smokers and non-smokers, with a clinical diagnosis of AR and positive Skin Prick Test (SPT). Smoking status was confirmed by salivary cotinine measurements. Functional respiratory evaluation was performed, and quality of life between groups was compared using Mini-RQLQ questionnaire. Immunological markers in serum and nasal washes (IgE, IL-4, IL 5, IL 13, IL 17, IL 33) were evaluated, while samples from a third group of passive smokers was incorporated for serological comparison exclusively. The statistical analysis included Student T test, x2, Mann Whitney U (Anova 2-way), and Kruskal Wallis for 3 groups analysis. Values of P < 0.05 were considered significant. Results: Twenty-two patients per group with similar demographics and allergen sensitivity were studied. Regarding inflammatory markers, a reduction of IL 33 in the serum of smokers (P < 0.001) was the only statistically significant different parameter revealed, showing a remarkable trend in nasal lavage. Salivary cotinine levels were absolutely different (P < 0.0001), but pulmonary function evaluations were not statistically significant after multiple adjusting. There were no significant differences in quality of life parameters. Conclusions: In our study of AR, active smokers do not demonstrate impaired nasal related quality of life or impact on atopic inflammatory parameters, compared to non-smokers. Reduced levels of IL33 could explain a lack of symptoms alerting smokers of the harmful consequences of smoking. Elsevier Inc. 2021-02 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/3467/1/A_Gomez_Croce_Zernotti.pdf Gómez, René Maximiliano, Croce, Víctor Hugo, Zernotti, Mario Emilio ORCID: https://orcid.org/0000-0003-4288-2809 <https://orcid.org/0000-0003-4288-2809> and Muiño, Juan Carlos (2021) Active smoking effect in allergic rhinitis. World Allergy Organization Journal, 14 (2). ISSN 1939-4551 https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.waojou.2020.100504&locationID=1&categoryID=4&eid=2-s2.0-85099368368&issn=19394551&linkType=ViewAtPublisher&year=2021&origin=recordpage&dig=b5c6d74e064d3bbbf2f562a287603fb1 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.waojou.2020.100504
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
RF Otorrinolaringología
spellingShingle R Medicina (General)
RF Otorrinolaringología
Gómez, René Maximiliano
Croce, Víctor Hugo
Zernotti, Mario Emilio
Muiño, Juan Carlos
Active smoking effect in allergic rhinitis
topic_facet R Medicina (General)
RF Otorrinolaringología
description Background: Tobacco smoke has been described as causing increased prevalence of rhinitis symptoms and decreased atopy. Furthermore, these nasal symptoms and quality of life in smokers with Allergic Rhinitis (AR) were not significantly different to non-smokers. As a result of this duality, a comparison study between the quality of life and inflammatory markers of atopy among active smokers and non-smokers having AR was put forward. Material and methods: Cross-sectional study in adult smokers and non-smokers, with a clinical diagnosis of AR and positive Skin Prick Test (SPT). Smoking status was confirmed by salivary cotinine measurements. Functional respiratory evaluation was performed, and quality of life between groups was compared using Mini-RQLQ questionnaire. Immunological markers in serum and nasal washes (IgE, IL-4, IL 5, IL 13, IL 17, IL 33) were evaluated, while samples from a third group of passive smokers was incorporated for serological comparison exclusively. The statistical analysis included Student T test, x2, Mann Whitney U (Anova 2-way), and Kruskal Wallis for 3 groups analysis. Values of P < 0.05 were considered significant. Results: Twenty-two patients per group with similar demographics and allergen sensitivity were studied. Regarding inflammatory markers, a reduction of IL 33 in the serum of smokers (P < 0.001) was the only statistically significant different parameter revealed, showing a remarkable trend in nasal lavage. Salivary cotinine levels were absolutely different (P < 0.0001), but pulmonary function evaluations were not statistically significant after multiple adjusting. There were no significant differences in quality of life parameters. Conclusions: In our study of AR, active smokers do not demonstrate impaired nasal related quality of life or impact on atopic inflammatory parameters, compared to non-smokers. Reduced levels of IL33 could explain a lack of symptoms alerting smokers of the harmful consequences of smoking.
format Artículo
author Gómez, René Maximiliano
Croce, Víctor Hugo
Zernotti, Mario Emilio
Muiño, Juan Carlos
author_facet Gómez, René Maximiliano
Croce, Víctor Hugo
Zernotti, Mario Emilio
Muiño, Juan Carlos
author_sort Gómez, René Maximiliano
title Active smoking effect in allergic rhinitis
title_short Active smoking effect in allergic rhinitis
title_full Active smoking effect in allergic rhinitis
title_fullStr Active smoking effect in allergic rhinitis
title_full_unstemmed Active smoking effect in allergic rhinitis
title_sort active smoking effect in allergic rhinitis
publisher Elsevier Inc.
publishDate 2021
url http://pa.bibdigital.ucc.edu.ar/3467/1/A_Gomez_Croce_Zernotti.pdf
work_keys_str_mv AT gomezrenemaximiliano activesmokingeffectinallergicrhinitis
AT crocevictorhugo activesmokingeffectinallergicrhinitis
AT zernottimarioemilio activesmokingeffectinallergicrhinitis
AT muinojuancarlos activesmokingeffectinallergicrhinitis
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