Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)

The rising incidence of adenocarcinoma in Barrett's esophagus has intensified the research into methods of early recognition of cancer risk, detecting cytological and architectural changes (dysplasia) or using biomarkers as predictive tests. The aim of this paper is to evaluate the involvement...

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Autores principales: Trakal, Esteban, Guidi, Andrés Emilio, Butti, Abel Luis L., Trakal, Juan José, Sambuelli, Rubén Horacio, Zárate, Fabián Eduardo
Formato: Artículo acceptedVersion
Lenguaje:Español
Publicado: Sociedad Argentina de Gastroenterología 2010
Materias:
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3444/1/A_Trakal_Guidi_Butti_Trakal_Sambuelli_Zarate.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3444
record_format dspace
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
spellingShingle R Medicina (General)
Trakal, Esteban
Guidi, Andrés Emilio
Butti, Abel Luis L.
Trakal, Juan José
Sambuelli, Rubén Horacio
Zárate, Fabián Eduardo
Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)
topic_facet R Medicina (General)
description The rising incidence of adenocarcinoma in Barrett's esophagus has intensified the research into methods of early recognition of cancer risk, detecting cytological and architectural changes (dysplasia) or using biomarkers as predictive tests. The aim of this paper is to evaluate the involvement of two tumor markers: p53 (tumor suppressor gene) and Ki67 (proliferation marker), by means of immunohistochemical analysis with monoclonal antibodies designed for the specific localization of p53 and Ki67 antigens, in esophageal biopsies with columnar metaplasia of patients with and without dysplasia and adenocarcinoma, and to anticipate which ones are liable to suffer it in the future. Both markers were positive in all intestinal metaplasia patients with high-grade dysplasia and adenocarcinoma, and even in some cases with low grade or without dysplasia. In contrast, in those who have gastric metaplasia, tumor markers were negative. Expression of biomarkers next to dysplasia reduces interobserver variation. Patients with these abnormalities have to be included into a surveillance protocol.
format Artículo
Artículo
acceptedVersion
author Trakal, Esteban
Guidi, Andrés Emilio
Butti, Abel Luis L.
Trakal, Juan José
Sambuelli, Rubén Horacio
Zárate, Fabián Eduardo
author_facet Trakal, Esteban
Guidi, Andrés Emilio
Butti, Abel Luis L.
Trakal, Juan José
Sambuelli, Rubén Horacio
Zárate, Fabián Eduardo
author_sort Trakal, Esteban
title Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)
title_short Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)
title_full Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)
title_fullStr Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)
title_full_unstemmed Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)
title_sort detection of the risk of adenocarcinoma in barrett's esophagus by means of tumor markers (p53 and ki67)
publisher Sociedad Argentina de Gastroenterología
publishDate 2010
url http://pa.bibdigital.ucc.edu.ar/3444/1/A_Trakal_Guidi_Butti_Trakal_Sambuelli_Zarate.pdf
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