Pan-cancer molecular patterns and biological implications associated with a tumor-specific molecular signature

Studying tissue-independent components of cancer and defining pan-cancer subtypes could be addressed using tissue-specific molecular signatures if classification errors are controlled. Since PAM50 is a well-known, United States Food and Drug Administration (FDA)-approved and commercially available b...

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Detalles Bibliográficos
Autores principales: Rocha, Darío, García, Iris A., Montoro, Aldana González, Llera, Andrea Sabina, Prato, Laura, Girotti, María Romina, Soria, Gastón, Fernández, Elmer Andrés
Formato: Artículo
Lenguaje:Español
Publicado: MDPI 2020
Materias:
R Medicina (General)
RC0254 Neoplasias. Los tumores. Oncología (incluyendo cáncer)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3389/1/A_Rocha_Garcia_Montoro.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3389
record_format dspace
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
RC0254 Neoplasias. Los tumores. Oncología (incluyendo cáncer)
spellingShingle R Medicina (General)
RC0254 Neoplasias. Los tumores. Oncología (incluyendo cáncer)
Rocha, Darío
García, Iris A.
Montoro, Aldana González
Llera, Andrea Sabina
Prato, Laura
Girotti, María Romina
Soria, Gastón
Fernández, Elmer Andrés
Pan-cancer molecular patterns and biological implications associated with a tumor-specific molecular signature
topic_facet R Medicina (General)
RC0254 Neoplasias. Los tumores. Oncología (incluyendo cáncer)
description Studying tissue-independent components of cancer and defining pan-cancer subtypes could be addressed using tissue-specific molecular signatures if classification errors are controlled. Since PAM50 is a well-known, United States Food and Drug Administration (FDA)-approved and commercially available breast cancer signature, we applied it with uncertainty assessment to classify tumor samples from over 33 cancer types, discarded unassigned samples, and studied the emerging tumor-agnostic molecular patterns. The percentage of unassigned samples ranged between 55.5% and 86.9% in non-breast tissues, and gene set analysis suggested that the remaining samples could be grouped into two classes (named C1 and C2) regardless of the tissue. The C2 class was more dedifferentiated, more proliferative, with higher centrosome amplification, and potentially more TP53 and RB1 mutations. We identified 28 gene sets and 95 genes mainly associated with cell-cycle progression, cell-cycle checkpoints, and DNA damage that were consistently exacerbated in the C2 class. In some cancer types, the C1/C2 classification was associated with survival and drug sensitivity, and modulated the prognostic meaning of the immune infiltrate. Our results suggest that PAM50 could be repurposed for a pan-cancer context when paired with uncertainty assessment, resulting in two classes with molecular, biological, and clinical implications.
format Artículo
Artículo
author Rocha, Darío
García, Iris A.
Montoro, Aldana González
Llera, Andrea Sabina
Prato, Laura
Girotti, María Romina
Soria, Gastón
Fernández, Elmer Andrés
author_facet Rocha, Darío
García, Iris A.
Montoro, Aldana González
Llera, Andrea Sabina
Prato, Laura
Girotti, María Romina
Soria, Gastón
Fernández, Elmer Andrés
author_sort Rocha, Darío
title Pan-cancer molecular patterns and biological implications associated with a tumor-specific molecular signature
title_short Pan-cancer molecular patterns and biological implications associated with a tumor-specific molecular signature
title_full Pan-cancer molecular patterns and biological implications associated with a tumor-specific molecular signature
title_fullStr Pan-cancer molecular patterns and biological implications associated with a tumor-specific molecular signature
title_full_unstemmed Pan-cancer molecular patterns and biological implications associated with a tumor-specific molecular signature
title_sort pan-cancer molecular patterns and biological implications associated with a tumor-specific molecular signature
publisher MDPI
publishDate 2020
url http://pa.bibdigital.ucc.edu.ar/3389/1/A_Rocha_Garcia_Montoro.pdf
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