Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival

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Oral squamous cell carcinoma (OSCC) is one of the most frequent types of oral cancer in developing countries and its burden correlates with exposure to tobacco and excessive alcohol consumption. Toll like receptors (TLRs) are major sensors of inflammatory stimuli, from both microbial and sterile cau...

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Autores principales: Bolesina, Nicolás, Gatti, Gerardo, López de Blanc, Silvia, Dhooge, Sabrina, Rocha, Darío, Fernández, Elmer Andrés, Ferreyra, Ruth, Palla, Vanesa, Grupe, Verónica, Morelatto, Rosana, Maccioni, Mariana
Formato: Artículo
Lenguaje:Español
Publicado: Frontiers Media S.A. 2022
Materias:
R Medicina (General)
RC0254 Neoplasias. Los tumores. Oncología (incluyendo cáncer)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3324/1/A_Bolesina_Gatti_Lopez%20de%20Blanc.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3324
record_format dspace
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
RC0254 Neoplasias. Los tumores. Oncología (incluyendo cáncer)
spellingShingle R Medicina (General)
RC0254 Neoplasias. Los tumores. Oncología (incluyendo cáncer)
Bolesina, Nicolás
Gatti, Gerardo
López de Blanc, Silvia
Dhooge, Sabrina
Rocha, Darío
Fernández, Elmer Andrés
Ferreyra, Ruth
Palla, Vanesa
Grupe, Verónica
Morelatto, Rosana
Maccioni, Mariana
Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival
topic_facet R Medicina (General)
RC0254 Neoplasias. Los tumores. Oncología (incluyendo cáncer)
description Oral squamous cell carcinoma (OSCC) is one of the most frequent types of oral cancer in developing countries and its burden correlates with exposure to tobacco and excessive alcohol consumption. Toll like receptors (TLRs) are major sensors of inflammatory stimuli, from both microbial and sterile causes and as such, they have been related to tumor progression and metastasis. Here, we evaluated the expression of TLR2, 4 and 9 as well as CD3+, CD8+ and Granzyme B+ cell infiltration by immunohistochemistry in oral samples of 30 patients with OSCC, classified according to their consumption of alcohol. Our findings indicate that there is a significant association between heavy alcohol consumption and tumors with higher expression levels of TLR9. Moreover, patients with TLR9high tumors, as well as those who indicated high consumption of alcohol exhibited a diminished overall survival. TCGA data analysis indicated that TLR9high tumors express a significant increase in some genes related with the oral cavity itself, inflammation and tumor promotion. Our analysis of tumor infiltrating leukocytes demonstrated that the major differences perceived in heavy alcohol consumers was the location of CD8+ T cells infiltrating the tumor, which showed lower numbers intratumorally. Our data suggest the existence of a pathogenic loop that involves alcohol consumption, high TLR9 expression and the immunophenotype, which might have a profound impact on the progression of the disease. Copyright
format Artículo
Artículo
author Bolesina, Nicolás
Gatti, Gerardo
López de Blanc, Silvia
Dhooge, Sabrina
Rocha, Darío
Fernández, Elmer Andrés
Ferreyra, Ruth
Palla, Vanesa
Grupe, Verónica
Morelatto, Rosana
Maccioni, Mariana
author_facet Bolesina, Nicolás
Gatti, Gerardo
López de Blanc, Silvia
Dhooge, Sabrina
Rocha, Darío
Fernández, Elmer Andrés
Ferreyra, Ruth
Palla, Vanesa
Grupe, Verónica
Morelatto, Rosana
Maccioni, Mariana
author_sort Bolesina, Nicolás
title Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival
title_short Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival
title_full Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival
title_fullStr Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival
title_full_unstemmed Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival
title_sort oral squamous cell carcinoma (oscc) tumors from heavy alcohol consumers are associated with higher levels of tlr9 and a particular immunophenotype: impact on patient survival
publisher Frontiers Media S.A.
publishDate 2022
url http://pa.bibdigital.ucc.edu.ar/3324/1/A_Bolesina_Gatti_Lopez%20de%20Blanc.pdf
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