Chronic kidney disease and clear renal cell carcinoma metastasis following radical or partial nephrectomy [Enfermedad renal crónica y aparición de metástasis posterior a nefrectomía radical y parcial por carcinoma renal de células claras]

Introduction: Partial nephrectomy to treat early-stage renal cell carcinoma has become one of the surgeries of choice for patients in Argentina. However, long-term results in the country are unknown. In this study, we analyzed the progression to chronic kidney disease and the appearance of metastasi...

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Autores principales: Fernández, Pehuén, De Arteaga, Javier, Chiurchiu, Carlos, Douthat, Walter Guillermo, Naser, Sofía, Schwarz, Facundo, Borgogno, Pamela, Colla, Raúl, Sosa, Alejandro, De La Fuente, Jorge
Formato: Artículo
Lenguaje:Español
Publicado: Asociacion Regional de Dialisi y Transplantes Renales de Capital Federal y Provincia de Buenos Aires 2021
Materias:
R Medicina (General)
RB Patología
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3322/1/A_Fernandez_De%20Arteaga_Chiurchiu.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3322
record_format dspace
spelling I38-R144-33222025-04-09T22:30:02Z http://pa.bibdigital.ucc.edu.ar/3322/ Chronic kidney disease and clear renal cell carcinoma metastasis following radical or partial nephrectomy [Enfermedad renal crónica y aparición de metástasis posterior a nefrectomía radical y parcial por carcinoma renal de células claras] Fernández, Pehuén De Arteaga, Javier Chiurchiu, Carlos Douthat, Walter Guillermo Naser, Sofía Schwarz, Facundo Borgogno, Pamela Colla, Raúl Sosa, Alejandro De La Fuente, Jorge R Medicina (General) RB Patología Introduction: Partial nephrectomy to treat early-stage renal cell carcinoma has become one of the surgeries of choice for patients in Argentina. However, long-term results in the country are unknown. In this study, we analyzed the progression to chronic kidney disease and the appearance of metastasis after partial or radical nephrectomy in renal cell carcinoma patients. Methods: A retrospective, cohort study was conducted. We included all patients suffering from T1 stage clear cell renal carcinoma who, between 2006 and 2012, underwent partial nephrectomy in our hospital. Follow-up continued until January 2018. Results: Thirty-two patients were included (19 had undergone radical nephrectomy and 13, partial nephrectomy). Subjects who had radical nephrectomy showed a more rapid progression to chronic kidney disease as compared to the subjects in the partial nephrectomy group (radical nephrectomy 63.2% vs. partial nephrectomy 15.4%; p=0.007). There were no differences in the follow-up period in both groups (radical nephrectomy 69.3% ± 23.8 months vs. partial nephrectomy 72.5 ± 26.9 months; p=0.73). Risk of progression to end-stage chronic kidney disease was 11 times higher for subjects who had undergone radical nephrectomy as compared to subjects who had had partial nephrectomy (adjusted HR 11.12; 95% CI: 1.24-99.9; p=0.031), adjusted by the rest of traditional risk factors. None of the T1a patients had metastasis during follow-up, regardless of the type of surgery. Conclusion: According to the findings of our study, partial nephrectomy preserves long-term renal function better than radical nephrectomy and has an excellent oncologic safety profile in T1a stage renal cell carcinoma patients. Radical nephrectomy was an independent risk factor of progression to chronic kidney disease. Asociacion Regional de Dialisi y Transplantes Renales de Capital Federal y Provincia de Buenos Aires 2021 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/3322/1/A_Fernandez_De%20Arteaga_Chiurchiu.pdf Fernández, Pehuén, De Arteaga, Javier, Chiurchiu, Carlos, Douthat, Walter Guillermo ORCID: https://orcid.org/0000-0002-4644-6003 <https://orcid.org/0000-0002-4644-6003>, Naser, Sofía, Schwarz, Facundo, Borgogno, Pamela, Colla, Raúl, Sosa, Alejandro and De La Fuente, Jorge (2021) Chronic kidney disease and clear renal cell carcinoma metastasis following radical or partial nephrectomy [Enfermedad renal crónica y aparición de metástasis posterior a nefrectomía radical y parcial por carcinoma renal de células claras]. Revista de Nefrologia, Dialisis y Trasplante, 41 (2). pp. 82-88. ISSN 0326-3428
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
RB Patología
spellingShingle R Medicina (General)
RB Patología
Fernández, Pehuén
De Arteaga, Javier
Chiurchiu, Carlos
Douthat, Walter Guillermo
Naser, Sofía
Schwarz, Facundo
Borgogno, Pamela
Colla, Raúl
Sosa, Alejandro
De La Fuente, Jorge
Chronic kidney disease and clear renal cell carcinoma metastasis following radical or partial nephrectomy [Enfermedad renal crónica y aparición de metástasis posterior a nefrectomía radical y parcial por carcinoma renal de células claras]
topic_facet R Medicina (General)
RB Patología
description Introduction: Partial nephrectomy to treat early-stage renal cell carcinoma has become one of the surgeries of choice for patients in Argentina. However, long-term results in the country are unknown. In this study, we analyzed the progression to chronic kidney disease and the appearance of metastasis after partial or radical nephrectomy in renal cell carcinoma patients. Methods: A retrospective, cohort study was conducted. We included all patients suffering from T1 stage clear cell renal carcinoma who, between 2006 and 2012, underwent partial nephrectomy in our hospital. Follow-up continued until January 2018. Results: Thirty-two patients were included (19 had undergone radical nephrectomy and 13, partial nephrectomy). Subjects who had radical nephrectomy showed a more rapid progression to chronic kidney disease as compared to the subjects in the partial nephrectomy group (radical nephrectomy 63.2% vs. partial nephrectomy 15.4%; p=0.007). There were no differences in the follow-up period in both groups (radical nephrectomy 69.3% ± 23.8 months vs. partial nephrectomy 72.5 ± 26.9 months; p=0.73). Risk of progression to end-stage chronic kidney disease was 11 times higher for subjects who had undergone radical nephrectomy as compared to subjects who had had partial nephrectomy (adjusted HR 11.12; 95% CI: 1.24-99.9; p=0.031), adjusted by the rest of traditional risk factors. None of the T1a patients had metastasis during follow-up, regardless of the type of surgery. Conclusion: According to the findings of our study, partial nephrectomy preserves long-term renal function better than radical nephrectomy and has an excellent oncologic safety profile in T1a stage renal cell carcinoma patients. Radical nephrectomy was an independent risk factor of progression to chronic kidney disease.
format Artículo
author Fernández, Pehuén
De Arteaga, Javier
Chiurchiu, Carlos
Douthat, Walter Guillermo
Naser, Sofía
Schwarz, Facundo
Borgogno, Pamela
Colla, Raúl
Sosa, Alejandro
De La Fuente, Jorge
author_facet Fernández, Pehuén
De Arteaga, Javier
Chiurchiu, Carlos
Douthat, Walter Guillermo
Naser, Sofía
Schwarz, Facundo
Borgogno, Pamela
Colla, Raúl
Sosa, Alejandro
De La Fuente, Jorge
author_sort Fernández, Pehuén
title Chronic kidney disease and clear renal cell carcinoma metastasis following radical or partial nephrectomy [Enfermedad renal crónica y aparición de metástasis posterior a nefrectomía radical y parcial por carcinoma renal de células claras]
title_short Chronic kidney disease and clear renal cell carcinoma metastasis following radical or partial nephrectomy [Enfermedad renal crónica y aparición de metástasis posterior a nefrectomía radical y parcial por carcinoma renal de células claras]
title_full Chronic kidney disease and clear renal cell carcinoma metastasis following radical or partial nephrectomy [Enfermedad renal crónica y aparición de metástasis posterior a nefrectomía radical y parcial por carcinoma renal de células claras]
title_fullStr Chronic kidney disease and clear renal cell carcinoma metastasis following radical or partial nephrectomy [Enfermedad renal crónica y aparición de metástasis posterior a nefrectomía radical y parcial por carcinoma renal de células claras]
title_full_unstemmed Chronic kidney disease and clear renal cell carcinoma metastasis following radical or partial nephrectomy [Enfermedad renal crónica y aparición de metástasis posterior a nefrectomía radical y parcial por carcinoma renal de células claras]
title_sort chronic kidney disease and clear renal cell carcinoma metastasis following radical or partial nephrectomy [enfermedad renal crónica y aparición de metástasis posterior a nefrectomía radical y parcial por carcinoma renal de células claras]
publisher Asociacion Regional de Dialisi y Transplantes Renales de Capital Federal y Provincia de Buenos Aires
publishDate 2021
url http://pa.bibdigital.ucc.edu.ar/3322/1/A_Fernandez_De%20Arteaga_Chiurchiu.pdf
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