Genome-wide identification of MITE-derived microRNAs and their targets in bread wheat
Background: Plant miRNAs are a class of small non-coding RNAs that can repress gene expression at the post-transcriptional level by targeting RNA degradation or promoting translational repression. There is increasing evidence that some miRNAs can derive from a group of non-autonomous class II transp...
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Autores principales: | , , , , , , |
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Formato: | Artículo |
Lenguaje: | Español |
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BioMed Central Ltd
2022
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Acceso en línea: | http://pa.bibdigital.ucc.edu.ar/3302/1/A_Crescente_del%20Vas_Asurmendi.pdf |
Aporte de: |
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I38-R144-3302 |
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institution |
Universidad Católica de Córdoba |
institution_str |
I-38 |
repository_str |
R-144 |
collection |
Producción Académica Universidad Católica de Córdoba (UCCor) |
language |
Español |
orig_language_str_mv |
spa |
topic |
Q Ciencia (General) QK Botánica |
spellingShingle |
Q Ciencia (General) QK Botánica Crescente, Juan M. Zavallo, Diego del Vas, Mariana Asurmendi, Sebastián Helguera, Marcelo Fernández, Elmer Andrés Vanzetti, Leonardo S. Genome-wide identification of MITE-derived microRNAs and their targets in bread wheat |
topic_facet |
Q Ciencia (General) QK Botánica |
description |
Background: Plant miRNAs are a class of small non-coding RNAs that can repress gene expression at the post-transcriptional level by targeting RNA degradation or promoting translational repression. There is increasing evidence that some miRNAs can derive from a group of non-autonomous class II transposable elements called Miniature Inverted-repeat Transposable Elements (MITEs). Results: We used public small RNA and degradome libraries from Triticum aestivum to screen for microRNAs production and predict their cleavage target sites. In parallel, we also created a comprehensive wheat MITE database by identifying novel elements and compiling known ones. When comparing both data sets, we found high homology between MITEs and 14% of all the miRNAs production sites detected. Furthermore, we show that MITE-derived miRNAs have preference for targeting degradation sites with MITE insertions in the 3’ UTR regions of the transcripts. Conclusions: Our results revealed that MITE-derived miRNAs can underlay the origin of some miRNAs and potentially shape a regulatory gene network. Since MITEs are found in millions of insertions in the wheat genome and are closely linked to genic regions, this kind of regulatory network could have a significant impact on the post-transcriptional control of gene expression. |
format |
Artículo Artículo |
author |
Crescente, Juan M. Zavallo, Diego del Vas, Mariana Asurmendi, Sebastián Helguera, Marcelo Fernández, Elmer Andrés Vanzetti, Leonardo S. |
author_facet |
Crescente, Juan M. Zavallo, Diego del Vas, Mariana Asurmendi, Sebastián Helguera, Marcelo Fernández, Elmer Andrés Vanzetti, Leonardo S. |
author_sort |
Crescente, Juan M. |
title |
Genome-wide identification of MITE-derived microRNAs and their targets in bread wheat |
title_short |
Genome-wide identification of MITE-derived microRNAs and their targets in bread wheat |
title_full |
Genome-wide identification of MITE-derived microRNAs and their targets in bread wheat |
title_fullStr |
Genome-wide identification of MITE-derived microRNAs and their targets in bread wheat |
title_full_unstemmed |
Genome-wide identification of MITE-derived microRNAs and their targets in bread wheat |
title_sort |
genome-wide identification of mite-derived micrornas and their targets in bread wheat |
publisher |
BioMed Central Ltd |
publishDate |
2022 |
url |
http://pa.bibdigital.ucc.edu.ar/3302/1/A_Crescente_del%20Vas_Asurmendi.pdf |
work_keys_str_mv |
AT crescentejuanm genomewideidentificationofmitederivedmicrornasandtheirtargetsinbreadwheat AT zavallodiego genomewideidentificationofmitederivedmicrornasandtheirtargetsinbreadwheat AT delvasmariana genomewideidentificationofmitederivedmicrornasandtheirtargetsinbreadwheat AT asurmendisebastian genomewideidentificationofmitederivedmicrornasandtheirtargetsinbreadwheat AT helgueramarcelo genomewideidentificationofmitederivedmicrornasandtheirtargetsinbreadwheat AT fernandezelmerandres genomewideidentificationofmitederivedmicrornasandtheirtargetsinbreadwheat AT vanzettileonardos genomewideidentificationofmitederivedmicrornasandtheirtargetsinbreadwheat |
bdutipo_str |
Repositorios |
_version_ |
1764820535781359618 |