High-dose buprenorphine results in a greater occurrence of postoperative hyperthermia than morphine in a randomized clinical trial in cats undergoing ovariohysterectomy

OBJECTIVE To compare the thermoregulatory and analgesic effects of high-dose buprenorphine versus morphine in cats undergoing ovariohysterectomy. ANIMALS 94 client-owned cats. PROCEDURES Cats were randomized to receive either buprenorphine 0.24 mg/kg or morphine 0.1 mg/kg subcutaneously (SC) during...

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Autores principales: Martin-Flores, Manuel, Lorenzutti, Augusto Matías, Nugen, Sarah A., Boesch, Jordyn M., Kirch, Pati J., Merry, Hillary L., Campoy, Luis
Formato: Artículo
Lenguaje:Español
Publicado: American Veterinary Medical Association 2022
Materias:
Q Ciencia (General)
QL Zoología
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3298/1/A_Martin-Flores_Lorenzutti_Nugen.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3298
record_format dspace
spelling I38-R144-32982025-04-11T18:05:44Z http://pa.bibdigital.ucc.edu.ar/3298/ High-dose buprenorphine results in a greater occurrence of postoperative hyperthermia than morphine in a randomized clinical trial in cats undergoing ovariohysterectomy Martin-Flores, Manuel Lorenzutti, Augusto Matías Nugen, Sarah A. Boesch, Jordyn M. Kirch, Pati J. Merry, Hillary L. Campoy, Luis Q Ciencia (General) QL Zoología OBJECTIVE To compare the thermoregulatory and analgesic effects of high-dose buprenorphine versus morphine in cats undergoing ovariohysterectomy. ANIMALS 94 client-owned cats. PROCEDURES Cats were randomized to receive either buprenorphine 0.24 mg/kg or morphine 0.1 mg/kg subcutaneously (SC) during recovery from ovariohysterectomy. Body temperature measurements were obtained before anesthesia, during anesthesia (averaged), at extubation, and 2, 4, and 16 to 20 hours postoperatively. Signs of pain were assessed, and demographic characteristics were compared between groups. The effects of treatment and time on body temperature, point prevalence of hyperthermia (> 39.2 °C), and pain scores were compared with linear or generalized mixed-effect models. RESULTS Cats receiving morphine (vs. buprenorphine) were older and heavier (both, P ≤ 0.005). Other group characteristics did not differ between treatments. Cats receiving buprenorphine (vs. morphine) had higher postoperative temperatures (P = 0.03). At 2, 4, and 16 to 20 hours after extubation, the point prevalence of hyperthermia was greater (P = 0.001) for cats receiving buprenorphine (55% [26/47], 44% [21/47], and 62% [27/43], respectively) versus morphine (28% [13/46], 13% [6/46], and 47% [21/44], respectively). There were no differences in pain scores between groups or over time. Five cats receiving buprenorphine and 6 receiving morphine required rescue analgesia within the 24-hour period. CLINICAL RELEVANCE Administration of buprenorphine (0.24 mg/kg SC), compared with morphine (0.1 mg/kg SC), resulted in higher body temperatures without an apparent advantage with regard to analgesia during the first 20 postoperative hours than morphine. Opioid-induced postoperative hyperthermia could confound the diagnosis of fever from different sources. American Veterinary Medical Association 2022-05-08 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/3298/1/A_Martin-Flores_Lorenzutti_Nugen.pdf Martin-Flores, Manuel, Lorenzutti, Augusto Matías ORCID: https://orcid.org/0000-0002-9799-4499 <https://orcid.org/0000-0002-9799-4499>, Nugen, Sarah A., Boesch, Jordyn M., Kirch, Pati J., Merry, Hillary L. and Campoy, Luis (2022) High-dose buprenorphine results in a greater occurrence of postoperative hyperthermia than morphine in a randomized clinical trial in cats undergoing ovariohysterectomy. American Journal of Veterinary Research, 83 (6). ISSN 0002-9645 https://avmajournals.avma.org/view/journals/ajvr/83/6/ajvr.21.11.0183.xml info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.2460/ajvr.21.11.0183
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic Q Ciencia (General)
QL Zoología
spellingShingle Q Ciencia (General)
QL Zoología
Martin-Flores, Manuel
Lorenzutti, Augusto Matías
Nugen, Sarah A.
Boesch, Jordyn M.
Kirch, Pati J.
Merry, Hillary L.
Campoy, Luis
High-dose buprenorphine results in a greater occurrence of postoperative hyperthermia than morphine in a randomized clinical trial in cats undergoing ovariohysterectomy
topic_facet Q Ciencia (General)
QL Zoología
description OBJECTIVE To compare the thermoregulatory and analgesic effects of high-dose buprenorphine versus morphine in cats undergoing ovariohysterectomy. ANIMALS 94 client-owned cats. PROCEDURES Cats were randomized to receive either buprenorphine 0.24 mg/kg or morphine 0.1 mg/kg subcutaneously (SC) during recovery from ovariohysterectomy. Body temperature measurements were obtained before anesthesia, during anesthesia (averaged), at extubation, and 2, 4, and 16 to 20 hours postoperatively. Signs of pain were assessed, and demographic characteristics were compared between groups. The effects of treatment and time on body temperature, point prevalence of hyperthermia (> 39.2 °C), and pain scores were compared with linear or generalized mixed-effect models. RESULTS Cats receiving morphine (vs. buprenorphine) were older and heavier (both, P ≤ 0.005). Other group characteristics did not differ between treatments. Cats receiving buprenorphine (vs. morphine) had higher postoperative temperatures (P = 0.03). At 2, 4, and 16 to 20 hours after extubation, the point prevalence of hyperthermia was greater (P = 0.001) for cats receiving buprenorphine (55% [26/47], 44% [21/47], and 62% [27/43], respectively) versus morphine (28% [13/46], 13% [6/46], and 47% [21/44], respectively). There were no differences in pain scores between groups or over time. Five cats receiving buprenorphine and 6 receiving morphine required rescue analgesia within the 24-hour period. CLINICAL RELEVANCE Administration of buprenorphine (0.24 mg/kg SC), compared with morphine (0.1 mg/kg SC), resulted in higher body temperatures without an apparent advantage with regard to analgesia during the first 20 postoperative hours than morphine. Opioid-induced postoperative hyperthermia could confound the diagnosis of fever from different sources.
format Artículo
author Martin-Flores, Manuel
Lorenzutti, Augusto Matías
Nugen, Sarah A.
Boesch, Jordyn M.
Kirch, Pati J.
Merry, Hillary L.
Campoy, Luis
author_facet Martin-Flores, Manuel
Lorenzutti, Augusto Matías
Nugen, Sarah A.
Boesch, Jordyn M.
Kirch, Pati J.
Merry, Hillary L.
Campoy, Luis
author_sort Martin-Flores, Manuel
title High-dose buprenorphine results in a greater occurrence of postoperative hyperthermia than morphine in a randomized clinical trial in cats undergoing ovariohysterectomy
title_short High-dose buprenorphine results in a greater occurrence of postoperative hyperthermia than morphine in a randomized clinical trial in cats undergoing ovariohysterectomy
title_full High-dose buprenorphine results in a greater occurrence of postoperative hyperthermia than morphine in a randomized clinical trial in cats undergoing ovariohysterectomy
title_fullStr High-dose buprenorphine results in a greater occurrence of postoperative hyperthermia than morphine in a randomized clinical trial in cats undergoing ovariohysterectomy
title_full_unstemmed High-dose buprenorphine results in a greater occurrence of postoperative hyperthermia than morphine in a randomized clinical trial in cats undergoing ovariohysterectomy
title_sort high-dose buprenorphine results in a greater occurrence of postoperative hyperthermia than morphine in a randomized clinical trial in cats undergoing ovariohysterectomy
publisher American Veterinary Medical Association
publishDate 2022
url http://pa.bibdigital.ucc.edu.ar/3298/1/A_Martin-Flores_Lorenzutti_Nugen.pdf
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