Production of Oral Vaccines Based on Virus-Like Particles Pseudotyped with Protozoan-Surface Proteins

Giardia lamblia is the only known parasite that can inhabit the harsh upper gastrointestinal tract, where most of the digestive proteases are secreted. Intestinal and free-living protozoa express surface proteins containing an extraordinarily high percentage of cysteine. These cysteine-rich variant-...

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Detalles Bibliográficos
Autores principales: Rupil, Lucía Lara dir., del Carmen Serradell, Marianela, Luján, Hugo Daniel
Formato: Artículo
Lenguaje:Español
Publicado: Humana Press Inc. 2022
Materias:
QR180 Inmunología
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3241/1/A_Rupil_del%20Carmen%20Serradell_Lujan.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3241
record_format dspace
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic QR180 Inmunología
R Medicina (General)
spellingShingle QR180 Inmunología
R Medicina (General)
Rupil, Lucía Lara dir.
del Carmen Serradell, Marianela
Luján, Hugo Daniel
Production of Oral Vaccines Based on Virus-Like Particles Pseudotyped with Protozoan-Surface Proteins
topic_facet QR180 Inmunología
R Medicina (General)
description Giardia lamblia is the only known parasite that can inhabit the harsh upper gastrointestinal tract, where most of the digestive proteases are secreted. Intestinal and free-living protozoa express surface proteins containing an extraordinarily high percentage of cysteine. These cysteine-rich variant-specific surface proteins (VSPs) form a dense coat on the entire surface of Giardia trophozoites, that coat protects the parasite inside the host intestine. VSPs not only are resistant to proteolytic digestion, extreme pH and temperatures, but also stimulate host immune responses. These properties can be used to protect as well as to increase the immunogenicity of vaccine antigens for oral administration. The incorporation of VSPs onto virus-like particles bearing viral antigens allows oral administration of these vaccines, protecting the antigens from degradation and generating robust and protective immune responses. In this chapter we describe the development of this versatile vaccine platform for the generation of safe, stable, and efficient oral vaccines, including their production and validation, as well as the characterization of immune response to oral immunization.
format Artículo
Artículo
author Rupil, Lucía Lara dir.
del Carmen Serradell, Marianela
Luján, Hugo Daniel
author_facet Rupil, Lucía Lara dir.
del Carmen Serradell, Marianela
Luján, Hugo Daniel
author_sort Rupil, Lucía Lara dir.
title Production of Oral Vaccines Based on Virus-Like Particles Pseudotyped with Protozoan-Surface Proteins
title_short Production of Oral Vaccines Based on Virus-Like Particles Pseudotyped with Protozoan-Surface Proteins
title_full Production of Oral Vaccines Based on Virus-Like Particles Pseudotyped with Protozoan-Surface Proteins
title_fullStr Production of Oral Vaccines Based on Virus-Like Particles Pseudotyped with Protozoan-Surface Proteins
title_full_unstemmed Production of Oral Vaccines Based on Virus-Like Particles Pseudotyped with Protozoan-Surface Proteins
title_sort production of oral vaccines based on virus-like particles pseudotyped with protozoan-surface proteins
publisher Humana Press Inc.
publishDate 2022
url http://pa.bibdigital.ucc.edu.ar/3241/1/A_Rupil_del%20Carmen%20Serradell_Lujan.pdf
work_keys_str_mv AT rupillucialaradir productionoforalvaccinesbasedonviruslikeparticlespseudotypedwithprotozoansurfaceproteins
AT delcarmenserradellmarianela productionoforalvaccinesbasedonviruslikeparticlespseudotypedwithprotozoansurfaceproteins
AT lujanhugodaniel productionoforalvaccinesbasedonviruslikeparticlespseudotypedwithprotozoansurfaceproteins
bdutipo_str Repositorios
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