Treatment with gonadotropin-releasing hormone analogs (GnRHa) in childhood and adolescence [Tratamiento con análogos de la hormona liberadora de gonadotrofinas (aGnRH) en niñas, niños y adolescents]

For several decades, gonadotropin releasing hormone analogs (GnRHa) are the medical treatment selected for central precocious puberty (CPP) in girls and boys. They generate an inhibition of the hypothalamus-pituitary-gonadal axis decreasing LH, FSH, estradiol and testosterone secretion and, in this...

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Autores principales:	Boulgourdjian, Elisabeth M., Alonso, Guillermo, Arcari, Andrea, Bengolea, Sonia V., Costanzo, Mariana, D'Amato, Silvia, Keselman, Ana, Martin, Silvia, Pipman, Viviana R., Azrak, María S.
Formato:	Artículo
Lenguaje:	Español
Publicado:	Sociedad Argentina de Pediatria 2022
Materias:	R Medicina (General)
Acceso en línea:	http://pa.bibdigital.ucc.edu.ar/3226/1/A_Martin_Boulgourdjian_Alonso.pdf
Aporte de:	Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba

id	I38-R144-3226
record_format	dspace
spelling	I38-R144-32262025-04-07T19:37:59Z http://pa.bibdigital.ucc.edu.ar/3226/ Treatment with gonadotropin-releasing hormone analogs (GnRHa) in childhood and adolescence [Tratamiento con análogos de la hormona liberadora de gonadotrofinas (aGnRH) en niñas, niños y adolescents] Boulgourdjian, Elisabeth M. Alonso, Guillermo Arcari, Andrea Bengolea, Sonia V. Costanzo, Mariana D'Amato, Silvia Keselman, Ana Martin, Silvia Pipman, Viviana R. Azrak, María S. R Medicina (General) For several decades, gonadotropin releasing hormone analogs (GnRHa) are the medical treatment selected for central precocious puberty (CPP) in girls and boys. They generate an inhibition of the hypothalamus-pituitary-gonadal axis decreasing LH, FSH, estradiol and testosterone secretion and, in this way, they produce a regression of secondary sexual characters under treatment. In the last years, these analogs are also used in trans adolescents, in adolescents and young adults with oncological diseases, in some very particular situations in children with short stature and in patients with neurodevelopmental disorders. In Argentina the most commonly used formulations are triptorelin and leuprolide acetate depot forms. These analogs have proven both their efficacy and their safety. The aim of this paper is to review and update about the use of GnRHa in children and adolescents. Sociedad Argentina de Pediatria 2022 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/3226/1/A_Martin_Boulgourdjian_Alonso.pdf Boulgourdjian, Elisabeth M., Alonso, Guillermo, Arcari, Andrea, Bengolea, Sonia V., Costanzo, Mariana, D'Amato, Silvia, Keselman, Ana, Martin, Silvia, Pipman, Viviana R. and Azrak, María S. (2022) Treatment with gonadotropin-releasing hormone analogs (GnRHa) in childhood and adolescence [Tratamiento con análogos de la hormona liberadora de gonadotrofinas (aGnRH) en niñas, niños y adolescents]. Archivos Argentinos de Pediatria. ISSN 0325-0075 https://www.sap.org.ar/docs/publicaciones/archivosarg/2022/v120n1a24s.pdf info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.5546/aap.2022.S9
institution	Universidad Católica de Córdoba
institution_str	I-38
repository_str	R-144
collection	Producción Académica Universidad Católica de Córdoba (UCCor)
language	Español
orig_language_str_mv	spa
topic	R Medicina (General)
spellingShingle	R Medicina (General) Boulgourdjian, Elisabeth M. Alonso, Guillermo Arcari, Andrea Bengolea, Sonia V. Costanzo, Mariana D'Amato, Silvia Keselman, Ana Martin, Silvia Pipman, Viviana R. Azrak, María S. Treatment with gonadotropin-releasing hormone analogs (GnRHa) in childhood and adolescence [Tratamiento con análogos de la hormona liberadora de gonadotrofinas (aGnRH) en niñas, niños y adolescents]
topic_facet	R Medicina (General)
description	For several decades, gonadotropin releasing hormone analogs (GnRHa) are the medical treatment selected for central precocious puberty (CPP) in girls and boys. They generate an inhibition of the hypothalamus-pituitary-gonadal axis decreasing LH, FSH, estradiol and testosterone secretion and, in this way, they produce a regression of secondary sexual characters under treatment. In the last years, these analogs are also used in trans adolescents, in adolescents and young adults with oncological diseases, in some very particular situations in children with short stature and in patients with neurodevelopmental disorders. In Argentina the most commonly used formulations are triptorelin and leuprolide acetate depot forms. These analogs have proven both their efficacy and their safety. The aim of this paper is to review and update about the use of GnRHa in children and adolescents.
format	Artículo
author	Boulgourdjian, Elisabeth M. Alonso, Guillermo Arcari, Andrea Bengolea, Sonia V. Costanzo, Mariana D'Amato, Silvia Keselman, Ana Martin, Silvia Pipman, Viviana R. Azrak, María S.
author_facet	Boulgourdjian, Elisabeth M. Alonso, Guillermo Arcari, Andrea Bengolea, Sonia V. Costanzo, Mariana D'Amato, Silvia Keselman, Ana Martin, Silvia Pipman, Viviana R. Azrak, María S.
author_sort	Boulgourdjian, Elisabeth M.
title	Treatment with gonadotropin-releasing hormone analogs (GnRHa) in childhood and adolescence [Tratamiento con análogos de la hormona liberadora de gonadotrofinas (aGnRH) en niñas, niños y adolescents]
title_short	Treatment with gonadotropin-releasing hormone analogs (GnRHa) in childhood and adolescence [Tratamiento con análogos de la hormona liberadora de gonadotrofinas (aGnRH) en niñas, niños y adolescents]
title_full	Treatment with gonadotropin-releasing hormone analogs (GnRHa) in childhood and adolescence [Tratamiento con análogos de la hormona liberadora de gonadotrofinas (aGnRH) en niñas, niños y adolescents]
title_fullStr	Treatment with gonadotropin-releasing hormone analogs (GnRHa) in childhood and adolescence [Tratamiento con análogos de la hormona liberadora de gonadotrofinas (aGnRH) en niñas, niños y adolescents]
title_full_unstemmed	Treatment with gonadotropin-releasing hormone analogs (GnRHa) in childhood and adolescence [Tratamiento con análogos de la hormona liberadora de gonadotrofinas (aGnRH) en niñas, niños y adolescents]
title_sort	treatment with gonadotropin-releasing hormone analogs (gnrha) in childhood and adolescence [tratamiento con análogos de la hormona liberadora de gonadotrofinas (agnrh) en niñas, niños y adolescents]
publisher	Sociedad Argentina de Pediatria
publishDate	2022
url	http://pa.bibdigital.ucc.edu.ar/3226/1/A_Martin_Boulgourdjian_Alonso.pdf
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Treatment with gonadotropin-releasing hormone analogs (GnRHa) in childhood and adolescence [Tratamiento con análogos de la hormona liberadora de gonadotrofinas (aGnRH) en niñas, niños y adolescents]

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