Neonatal Blood Carnitine Concentrations: Normative Data by Electrospray Tandem Mass Spectometry

Despite a number of published reports, there is limited infor-mation about carnitine metabolism in the newborn. To establish normative data, we analyzed whole-blood carnitine concentra-tions in 24,644 newborns at age 1.85 0.95 d and umbilical cord whole blood and plasma carnitine concentrations in...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Chace, Donald H., Pons, Roser, Chiriboga, Claudia A., Mcmahon, Donald J., Tein, Ingrid, Naylor, Edwin W., De vivo, Darryl c.
Formato: Artículo
Lenguaje:Inglés
Publicado: Universidad de Belgrano - Documentos CEEGMD - Centro para el estudio de enfermedades genéticas, metabólicas y discapacidades. Facultad de Ciencias Exactas 2014
Materias:
acylcarnitine
red blood cells
radioenzyme
células rojas de la sangre
acilcarnitina
radioenzima
Acceso en línea:http://repositorio.ub.edu.ar/handle/123456789/2861
Aporte de:
Repositorio Institucional - Universidad de Belgrano (UB) de Universidad de Belgrano
id I36-R142-123456789-2861
record_format dspace
institution Universidad de Belgrano
institution_str I-36
repository_str R-142
collection Repositorio Institucional - Universidad de Belgrano (UB)
language Inglés
topic acylcarnitine
red blood cells
radioenzyme
células rojas de la sangre
acilcarnitina
radioenzima
spellingShingle acylcarnitine
red blood cells
radioenzyme
células rojas de la sangre
acilcarnitina
radioenzima
Chace, Donald H.
Pons, Roser
Chiriboga, Claudia A.
Mcmahon, Donald J.
Tein, Ingrid
Naylor, Edwin W.
De vivo, Darryl c.
Neonatal Blood Carnitine Concentrations: Normative Data by Electrospray Tandem Mass Spectometry
topic_facet acylcarnitine
red blood cells
radioenzyme
células rojas de la sangre
acilcarnitina
radioenzima
description Despite a number of published reports, there is limited infor-mation about carnitine metabolism in the newborn. To establish normative data, we analyzed whole-blood carnitine concentra-tions in 24,644 newborns at age 1.85 0.95 d and umbilical cord whole blood and plasma carnitine concentrations in 50 full-term newborns. Total carnitine (TC), free carnitine (FC), and acylcar-nitine (AC) were measured by electrospray tandem mass spec-trometry. AC/FC ratios were derived from these measurements. The entire cohort was stratified according to TC values into a middle TC group representing 90% of the population and lower and upper TC groups representing 5% of the population, respec-tively. Normative data were derived from the middle TC group of full-term infants (N 19,595). TC was 72.42 20.75 M, FC was 44.94 14.99 M, AC was 27.48 8.05 M, and AC/FC ratio was 0.64 0.19 ( SD). These values differed significantly from umbilical cord whole blood TC values of 31.27 10.54 M determined in 50 samples. No meaningful correlation was found between TC and gestational age or birth weight in any group. In controlled analyses, prematurity was not associated with TC levels, whereas low birth weight ( 2500 g) and male sex were significantly associated with higher TC levels. The association of low birth weight with higher TC values may be related to decreased tissue carnitine uptake. The sex effect may be related to hormonal influences on carnitine metabolism. Our study provides normative data of carnitine values measured by the highly precise method of electrospray tandem mass spec-trometry in a large cohort of newborns and provides the basis for future studies of carnitine metabolism in health and disease states during the neonatal period.
format Article
author Chace, Donald H.
Pons, Roser
Chiriboga, Claudia A.
Mcmahon, Donald J.
Tein, Ingrid
Naylor, Edwin W.
De vivo, Darryl c.
author_facet Chace, Donald H.
Pons, Roser
Chiriboga, Claudia A.
Mcmahon, Donald J.
Tein, Ingrid
Naylor, Edwin W.
De vivo, Darryl c.
author_sort Chace, Donald H.
title Neonatal Blood Carnitine Concentrations: Normative Data by Electrospray Tandem Mass Spectometry
title_short Neonatal Blood Carnitine Concentrations: Normative Data by Electrospray Tandem Mass Spectometry
title_full Neonatal Blood Carnitine Concentrations: Normative Data by Electrospray Tandem Mass Spectometry
title_fullStr Neonatal Blood Carnitine Concentrations: Normative Data by Electrospray Tandem Mass Spectometry
title_full_unstemmed Neonatal Blood Carnitine Concentrations: Normative Data by Electrospray Tandem Mass Spectometry
title_sort neonatal blood carnitine concentrations: normative data by electrospray tandem mass spectometry
publisher Universidad de Belgrano - Documentos CEEGMD - Centro para el estudio de enfermedades genéticas, metabólicas y discapacidades. Facultad de Ciencias Exactas
publishDate 2014
url http://repositorio.ub.edu.ar/handle/123456789/2861
work_keys_str_mv AT chacedonaldh neonatalbloodcarnitineconcentrationsnormativedatabyelectrospraytandemmassspectometry
AT ponsroser neonatalbloodcarnitineconcentrationsnormativedatabyelectrospraytandemmassspectometry
AT chiribogaclaudiaa neonatalbloodcarnitineconcentrationsnormativedatabyelectrospraytandemmassspectometry
AT mcmahondonaldj neonatalbloodcarnitineconcentrationsnormativedatabyelectrospraytandemmassspectometry
AT teiningrid neonatalbloodcarnitineconcentrationsnormativedatabyelectrospraytandemmassspectometry
AT nayloredwinw neonatalbloodcarnitineconcentrationsnormativedatabyelectrospraytandemmassspectometry
AT devivodarrylc neonatalbloodcarnitineconcentrationsnormativedatabyelectrospraytandemmassspectometry
bdutipo_str Repositorios
_version_ 1764820529502486528

Ejemplares similares