Relationship between copper doses in parenteral nutrition mixtures, serum copper, erythrocyte copper levels, ceruloplasmin and C-reactive protein, in critically ill patients
Background and aims: There is no consensus on the recommended amounts of copper to be administered to critically ill patients on parenteral nutrition, as requirements are variable and very difficult to determine in different disease states. The objective of this study was to assess copper status o...
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| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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Universidad de Belgrano - Facultad de Ciencias Exactas y Naturales - Proyectos de Investigación
2014
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| Materias: | |
| Acceso en línea: | http://repositorio.ub.edu.ar/handle/123456789/2770 |
| Aporte de: |
| id |
I36-R142-123456789-2770 |
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| record_format |
dspace |
| institution |
Universidad de Belgrano |
| institution_str |
I-36 |
| repository_str |
R-142 |
| collection |
Repositorio Institucional - Universidad de Belgrano (UB) |
| language |
Inglés |
| topic |
Adult critical patients Parenteral nutrition Copper doses Erythrocyte copper levels Serum copper levels Serum ceruloplasmin Pacientes críticos adultos nutrición parenteral dosis de cobre Niveles de cobre en eritrocitos niveles de cobre en suero |
| spellingShingle |
Adult critical patients Parenteral nutrition Copper doses Erythrocyte copper levels Serum copper levels Serum ceruloplasmin Pacientes críticos adultos nutrición parenteral dosis de cobre Niveles de cobre en eritrocitos niveles de cobre en suero Menéndez, Ana María Montemerlo, Hugo José Negri, Gustavo Weisstaub, Adriana Ruth Bustos Fernanda, Fernanda Yapur, Viviana Pita Martín de Portela, María Luz Relationship between copper doses in parenteral nutrition mixtures, serum copper, erythrocyte copper levels, ceruloplasmin and C-reactive protein, in critically ill patients |
| topic_facet |
Adult critical patients Parenteral nutrition Copper doses Erythrocyte copper levels Serum copper levels Serum ceruloplasmin Pacientes críticos adultos nutrición parenteral dosis de cobre Niveles de cobre en eritrocitos niveles de cobre en suero |
| description |
Background and aims: There is no consensus on the recommended amounts of copper to be administered
to critically ill patients on parenteral nutrition, as requirements are variable and very difficult to
determine in different disease states. The objective of this study was to assess copper status of critically
ill patients on total parenteral nutrition in order to prevent inadequate copper administration.
Methods: The study comprised adult patients (20 males and 10 females) requiring total parenteral
nutrition for 4e21 days, because of pancreatitis (n ¼ 5) or after major abdominal surgery (n ¼ 25).
Parenteral nutrition was discontinued when the patient tolerated enteral or oral feeding. The following
parameters were determined throughout the study (4e21 days): total copper administered by parenteral
nutrition, serum copper, erythrocyte copper (Atomic Absorption Spectrometry); serum ceruloplasmin
(Ferroxidase activity) and C-reactive protein levels (Immunoturbidimetry, Latex HS).
Results: Total copper administered in parenteral nutrition ranged between 0.03 and 3.8 mg/d, and was
higher than prescribed amounts due to copper contamination of individual components. The amount of
copper given in parenteral nutrition correlated with changes in erythrocyte copper, but not with changes
in serum copper, ceruloplasmin, or C-reactive protein.
Conclusions: Variations in erythrocyte copper levels showed significant correlation with the amount of
copper administered daily in parenteral nutrition mixtures, and this biochemical indicator could be
useful to monitor copper deficiency or excess in patients on parenteral nutrition. It is noteworthy that
copper delivery above 1.2 mg/d was frequent and prompts such monitoring. |
| format |
Article |
| author |
Menéndez, Ana María Montemerlo, Hugo José Negri, Gustavo Weisstaub, Adriana Ruth Bustos Fernanda, Fernanda Yapur, Viviana Pita Martín de Portela, María Luz |
| author_facet |
Menéndez, Ana María Montemerlo, Hugo José Negri, Gustavo Weisstaub, Adriana Ruth Bustos Fernanda, Fernanda Yapur, Viviana Pita Martín de Portela, María Luz |
| author_sort |
Menéndez, Ana María |
| title |
Relationship between copper doses in parenteral nutrition mixtures, serum copper, erythrocyte copper levels, ceruloplasmin and C-reactive protein, in critically ill patients |
| title_short |
Relationship between copper doses in parenteral nutrition mixtures, serum copper, erythrocyte copper levels, ceruloplasmin and C-reactive protein, in critically ill patients |
| title_full |
Relationship between copper doses in parenteral nutrition mixtures, serum copper, erythrocyte copper levels, ceruloplasmin and C-reactive protein, in critically ill patients |
| title_fullStr |
Relationship between copper doses in parenteral nutrition mixtures, serum copper, erythrocyte copper levels, ceruloplasmin and C-reactive protein, in critically ill patients |
| title_full_unstemmed |
Relationship between copper doses in parenteral nutrition mixtures, serum copper, erythrocyte copper levels, ceruloplasmin and C-reactive protein, in critically ill patients |
| title_sort |
relationship between copper doses in parenteral nutrition mixtures, serum copper, erythrocyte copper levels, ceruloplasmin and c-reactive protein, in critically ill patients |
| publisher |
Universidad de Belgrano - Facultad de Ciencias Exactas y Naturales - Proyectos de Investigación |
| publishDate |
2014 |
| url |
http://repositorio.ub.edu.ar/handle/123456789/2770 |
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Repositorios |
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