Influencia del zinc administrado a pacientes críticos con nutrición parenteral sobre los niveles de zinc plasmático, proteína C reactiva, interleuquina-6 y receptor soluble de interleuquina-6 - Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive c protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients.
Objectives:To study the interrelationship between serum Interleukin-6 (IL-6), serum Interleukin-6 soluble Receptor (IL-6 sR), C-Reactive Protein (C-RP), plasma-tic Zinc levels (PlZn) and their response in relation to Zn administered by TPN, in critical patients. Methods: 17 patients, receiving...
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| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Español |
| Publicado: |
Universidad de Belgrano - Facultad de Ciencias Exactas y Naturales - Proyectos de Investigación
2014
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| Materias: | |
| Acceso en línea: | http://repositorio.ub.edu.ar/handle/123456789/2765 |
| Aporte de: |
| Sumario: | Objectives:To study the interrelationship between
serum Interleukin-6 (IL-6), serum Interleukin-6 soluble
Receptor (IL-6 sR), C-Reactive Protein (C-RP), plasma-tic Zinc levels (PlZn) and their response in relation to Zn
administered by TPN, in critical patients.
Methods: 17 patients, receiving TPN as a consequence of
acute pancreatitis (n = 4) or after a major abdominal surgery
due to intestinal cancer (n = 7), intestinal fístula (n = 3), intes-tinal obstruction (n = 2) or intestinal íleus (n = 1) were stu-died. At the beginning (To) and at the end of the TPN admi-nistration (6-21days) serum IL-6 and IL-6 sR were
determined by ELISA; C-RP ultrasensitive (C-RP us) by
inmunoturbidimetric method; Zn was determined in TPN
and in plasma by Atomic Absorption Spectrometry. Charac-teristics of the patients were (mean ± SD and ranges): age:
60.6 ± 11.7 (37-77) years; BMI (kg/m
2
): 26.0 ± 3.4 (19.9-34.0).
Results:The results (mean ± standard deviation and ran-ges) were: Zn provided by TPN (mg/d): 6.1 ± 2.0 (range 2.8 to
10.8). Biochemical levels were, at To and Tf, respectively:
(mean±SD and ranges) were at To y Tf, respectively: Zn Pl
(μg/dl): 104 ± 46 (35-177); 120 ± 55 (52-229); IL-6 (pg/mL) 93
± 74 (10-262); 117 ± 180 (7-761); IL6sR (pg/mL): 1,012 ± 322
(589-1855); 1,269 ± 451 (631-2195); C-RP us (mg/L): 71 ± 63
(2-196); 65 ± 43 (0-137). There was no correlation between
variations of IL6, IL6sR, C-RP, PlZn levels and the daily
amount of Zn administered in the TPN mixtures. Two
patients presented a bad evolution; they received 4.2 and 5.2
md/d of Zn and showed an increase of IL6 levels, maintained
high levels of IL6sR but C-RP levels decreased
Conclusions:the range of 2.8 to 10.8 mg/d of Zn admi-nistered in TPN mixtures did not exacerbate the inflam-matory response |
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