Early Distal Axonopathy of the Visual Pathway in Experimental Diabetes
Diabetic retinopathy is a leading cause of acquired blindness. Visual function disorders have been observed in diabetic patients with very early retinopathy or even before the onset of retinopathy. The aim of the present work was to analyze the visual pathway in an early stage of experimental dia...
Guardado en:
| Autores principales: | , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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Universidad de Belgrano - Facultad de Ciencias de la Salud - Proyectos de Investigación
2014
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| Materias: | |
| Acceso en línea: | http://repositorio.ub.edu.ar/handle/123456789/2744 |
| Aporte de: |
| id |
I36-R142-123456789-2744 |
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| record_format |
dspace |
| institution |
Universidad de Belgrano |
| institution_str |
I-36 |
| repository_str |
R-142 |
| collection |
Repositorio Institucional - Universidad de Belgrano (UB) |
| language |
Inglés |
| topic |
Diabetes Early Distal Axonopathy Temprana Distal axonopatía Visual Pathway vías ópticas |
| spellingShingle |
Diabetes Early Distal Axonopathy Temprana Distal axonopatía Visual Pathway vías ópticas Fernandez, Diego C. Pasquini, Laura A. Dorfman, Damián Aldana Marcos, Hernán J. Rosenstein, Ruth E. Early Distal Axonopathy of the Visual Pathway in Experimental Diabetes |
| topic_facet |
Diabetes Early Distal Axonopathy Temprana Distal axonopatía Visual Pathway vías ópticas |
| description |
Diabetic retinopathy is a leading cause of acquired blindness. Visual function disorders have been
observed in diabetic patients with very early retinopathy or even before the onset of retinopathy.
The aim of the present work was to analyze the visual pathway in an early stage of experimental
diabetes. Diabetes was induced in Wistar rats by an i.p. injection of streptozotocin. A deficit in
anterograde transport from the retina to the superior colliculus was observed 6 weeks after
streptozotocin injection. At this time point, morphologic studies did not reveal retinal ganglion cell
loss or substantial alterations in the superior colliculus. The optic nerve was morphometrically
evaluated at intraorbital (unmyelinated and myelinated) and intracranial sections. In animals that
had been diabetic for 6 weeks, a large increase in astrocyte reactivity occurred in the distal (but not
the intraorbital) portion, which coincided with significant axon loss. Moreover, profound myelin
alterations and altered morphologic features of oligodendrocyte lineage were observed at the distal
(but not the proximal) optic nerve portion. The present results suggest that axoglial alterations at
the distal portion of the optic nerve could be the first structural change in the diabetic visual
pathway. |
| format |
Article |
| author |
Fernandez, Diego C. Pasquini, Laura A. Dorfman, Damián Aldana Marcos, Hernán J. Rosenstein, Ruth E. |
| author_facet |
Fernandez, Diego C. Pasquini, Laura A. Dorfman, Damián Aldana Marcos, Hernán J. Rosenstein, Ruth E. |
| author_sort |
Fernandez, Diego C. |
| title |
Early Distal Axonopathy of the Visual Pathway in Experimental Diabetes |
| title_short |
Early Distal Axonopathy of the Visual Pathway in Experimental Diabetes |
| title_full |
Early Distal Axonopathy of the Visual Pathway in Experimental Diabetes |
| title_fullStr |
Early Distal Axonopathy of the Visual Pathway in Experimental Diabetes |
| title_full_unstemmed |
Early Distal Axonopathy of the Visual Pathway in Experimental Diabetes |
| title_sort |
early distal axonopathy of the visual pathway in experimental diabetes |
| publisher |
Universidad de Belgrano - Facultad de Ciencias de la Salud - Proyectos de Investigación |
| publishDate |
2014 |
| url |
http://repositorio.ub.edu.ar/handle/123456789/2744 |
| work_keys_str_mv |
AT fernandezdiegoc earlydistalaxonopathyofthevisualpathwayinexperimentaldiabetes AT pasquinilauraa earlydistalaxonopathyofthevisualpathwayinexperimentaldiabetes AT dorfmandamian earlydistalaxonopathyofthevisualpathwayinexperimentaldiabetes AT aldanamarcoshernanj earlydistalaxonopathyofthevisualpathwayinexperimentaldiabetes AT rosensteinruthe earlydistalaxonopathyofthevisualpathwayinexperimentaldiabetes |
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Repositorios |
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