Ischemic Conditioning Protects from Axoglial Alterations of the Optic Pathway Induced by Experimental Diabetes in Rats

Diabetic retinopathy is a leading cause of blindness. Visual function disorders have been demonstrated in diabetics even before the onset of retinopathy. At early stages of experimental diabetes, axoglial alterations occur at the distal portion of the optic nerve. Although ischemic conditioning ca...

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Autores principales: Fernandez, Diego C., Pasquini, Laura A., Dorfman, Damián, Aldana Marcos, Hernán J., Rosenstein, Ruth E.
Formato: Artículo
Lenguaje:Inglés
Publicado: Universidad de Belgrano - Facultad de Ciencias de la Salud - Proyectos de Investigación 2014
Materias:
Ischemic
Axoglial Alterations
Diabetes
isquémica
Rats
ratas
Optic Pathway
Camino óptico
Acceso en línea:http://repositorio.ub.edu.ar/handle/123456789/2741
Aporte de:
Repositorio Institucional - Universidad de Belgrano (UB) de Universidad de Belgrano
id I36-R142-123456789-2741
record_format dspace
institution Universidad de Belgrano
institution_str I-36
repository_str R-142
collection Repositorio Institucional - Universidad de Belgrano (UB)
language Inglés
topic Ischemic
Axoglial Alterations
Diabetes
isquémica
Rats
ratas
Optic Pathway
Camino óptico
spellingShingle Ischemic
Axoglial Alterations
Diabetes
isquémica
Rats
ratas
Optic Pathway
Camino óptico
Fernandez, Diego C.
Pasquini, Laura A.
Dorfman, Damián
Aldana Marcos, Hernán J.
Rosenstein, Ruth E.
Ischemic Conditioning Protects from Axoglial Alterations of the Optic Pathway Induced by Experimental Diabetes in Rats
topic_facet Ischemic
Axoglial Alterations
Diabetes
isquémica
Rats
ratas
Optic Pathway
Camino óptico
description Diabetic retinopathy is a leading cause of blindness. Visual function disorders have been demonstrated in diabetics even before the onset of retinopathy. At early stages of experimental diabetes, axoglial alterations occur at the distal portion of the optic nerve. Although ischemic conditioning can protect neurons and synaptic terminals against ischemic damage, there is no information on its ability to protect axons. We analyzed the effect of ischemic conditioning on the early axoglial alterations in the distal portion of the optic nerve induced by experimental diabetes. Diabetes was induced in Wistar rats by an intraperitoneal injection of streptozotocin. Retinal ischemia was induced by increasing intraocular pressure to 120 mm Hg for 5 min; this maneuver started 3 days after streptozotocin injection and was weekly repeated in one eye, while the contralateral eye was submitted to a sham procedure. The application of ischemia pulses prevented a deficit in the anterograde transport from the retina to the superior colliculus, as well as an increase in astrocyte reactivity, ultraestructural myelin alterations, and altered morphology of oligodendrocyte lineage in the optic nerve distal portion at early stages of experimental diabetes. Ischemia tolerance prevented a significant decrease of retinal glutamine synthetase activity induced by diabetes. These results suggest that early vision loss in diabetes could be abated by ischemic conditioning which preserved axonal function and structure.
format Article
author Fernandez, Diego C.
Pasquini, Laura A.
Dorfman, Damián
Aldana Marcos, Hernán J.
Rosenstein, Ruth E.
author_facet Fernandez, Diego C.
Pasquini, Laura A.
Dorfman, Damián
Aldana Marcos, Hernán J.
Rosenstein, Ruth E.
author_sort Fernandez, Diego C.
title Ischemic Conditioning Protects from Axoglial Alterations of the Optic Pathway Induced by Experimental Diabetes in Rats
title_short Ischemic Conditioning Protects from Axoglial Alterations of the Optic Pathway Induced by Experimental Diabetes in Rats
title_full Ischemic Conditioning Protects from Axoglial Alterations of the Optic Pathway Induced by Experimental Diabetes in Rats
title_fullStr Ischemic Conditioning Protects from Axoglial Alterations of the Optic Pathway Induced by Experimental Diabetes in Rats
title_full_unstemmed Ischemic Conditioning Protects from Axoglial Alterations of the Optic Pathway Induced by Experimental Diabetes in Rats
title_sort ischemic conditioning protects from axoglial alterations of the optic pathway induced by experimental diabetes in rats
publisher Universidad de Belgrano - Facultad de Ciencias de la Salud - Proyectos de Investigación
publishDate 2014
url http://repositorio.ub.edu.ar/handle/123456789/2741
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