A facile one-pot synthesis of 8-oxo-7,8-dihydro-(2′-deoxy)adenosine in water

Reaction of 2-mercaptoethanol with 8-bromo-2′-deoxyadenosine and 8-bromo-adenosine in aqueous solution and in the presence of triethylamine gave the 8-oxo-adenine derivatives in very good yields. Some mechanistic details are reported.

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Detalles Bibliográficos
Autores principales: Chryssostomos, Chatgilialoglu, Navacchia, Maria Luisa, Postigo, Al
Formato: Artículo
Lenguaje:Inglés
Publicado: Universidad de Belgrano - Facultad de Ciencias Exactas y Naturales - Proyectos de Investigación 2014
Materias:
DNA damage
Nucleosides
Mercaptoethanol
daño en el ADN
Nucleósidos
Mercaptoetanol
Acceso en línea:http://repositorio.ub.edu.ar/handle/123456789/2727
Aporte de:
Repositorio Institucional - Universidad de Belgrano (UB) de Universidad de Belgrano
id I36-R142-123456789-2727
record_format dspace
institution Universidad de Belgrano
institution_str I-36
repository_str R-142
collection Repositorio Institucional - Universidad de Belgrano (UB)
language Inglés
topic DNA damage
Nucleosides
Mercaptoethanol
daño en el ADN
Nucleósidos
Mercaptoetanol
spellingShingle DNA damage
Nucleosides
Mercaptoethanol
daño en el ADN
Nucleósidos
Mercaptoetanol
Chryssostomos, Chatgilialoglu
Navacchia, Maria Luisa
Postigo, Al
A facile one-pot synthesis of 8-oxo-7,8-dihydro-(2′-deoxy)adenosine in water
topic_facet DNA damage
Nucleosides
Mercaptoethanol
daño en el ADN
Nucleósidos
Mercaptoetanol
description Reaction of 2-mercaptoethanol with 8-bromo-2′-deoxyadenosine and 8-bromo-adenosine in aqueous solution and in the presence of triethylamine gave the 8-oxo-adenine derivatives in very good yields. Some mechanistic details are reported.
format Article
author Chryssostomos, Chatgilialoglu
Navacchia, Maria Luisa
Postigo, Al
author_facet Chryssostomos, Chatgilialoglu
Navacchia, Maria Luisa
Postigo, Al
author_sort Chryssostomos, Chatgilialoglu
title A facile one-pot synthesis of 8-oxo-7,8-dihydro-(2′-deoxy)adenosine in water
title_short A facile one-pot synthesis of 8-oxo-7,8-dihydro-(2′-deoxy)adenosine in water
title_full A facile one-pot synthesis of 8-oxo-7,8-dihydro-(2′-deoxy)adenosine in water
title_fullStr A facile one-pot synthesis of 8-oxo-7,8-dihydro-(2′-deoxy)adenosine in water
title_full_unstemmed A facile one-pot synthesis of 8-oxo-7,8-dihydro-(2′-deoxy)adenosine in water
title_sort facile one-pot synthesis of 8-oxo-7,8-dihydro-(2′-deoxy)adenosine in water
publisher Universidad de Belgrano - Facultad de Ciencias Exactas y Naturales - Proyectos de Investigación
publishDate 2014
url http://repositorio.ub.edu.ar/handle/123456789/2727
work_keys_str_mv AT chryssostomoschatgilialoglu afacileonepotsynthesisof8oxo78dihydro2deoxyadenosineinwater
AT navacchiamarialuisa afacileonepotsynthesisof8oxo78dihydro2deoxyadenosineinwater
AT postigoal afacileonepotsynthesisof8oxo78dihydro2deoxyadenosineinwater
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AT navacchiamarialuisa facileonepotsynthesisof8oxo78dihydro2deoxyadenosineinwater
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