Understanding the Process ofEnvelope Glycoprotein Incorporation into Virions in Simian and Feline Immunodeficiency Viruses
The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis. Therefore, Env incorporation into the virions formed by assembly of the viral Gag polyprotein at the plasma me...
Guardado en:
| Autores principales: | , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Universidad de Belgrano - Facultad de Ciencias Exactas y Naturales - Proyectos de Investigación
2014
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| Materias: | |
| Acceso en línea: | http://repositorio.ub.edu.ar/handle/123456789/2718 |
| Aporte de: |
| Sumario: | The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting
with specific receptors present at the cell surface, thereby determining viral tropism and
pathogenesis. Therefore, Env incorporation into the virions formed by assembly of the viral
Gag polyprotein at the plasma membrane of the infected cells is a key step in the replication
cycle of lentiviruses. Besides being usefulmodels of human immunodeficiency virus
(HIV) infections in humans and valuable tools for developing AIDS therapies and vaccines,
simian and feline immunodeficiency viruses (SIV and FIV, respectively) are relevant animal
retroviruses; the study of which provides important information on how lentiviral replication
strategies have evolved. In this review, we discuss the molecular mechanisms underlying the
incorporation of the SIV and FIV Env glycoproteins into viral particles. |
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