Role of astrocytic dysfunction in the pathogenesis of parkinson’s disease animal models from a molecular signaling perspective

Resumen: Despite the fact that astrocytes are the most abundant glial cells, critical for brain function, few studies have dealt with their possible role in neurodegenerative diseases like Parkinson’s disease (PD). This article explores relevant evidence on the involvement of astrocytes in experim...

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Detalles Bibliográficos
Autores principales: Udovin, Lucas Daniel, Quarracino, Cecilia, Herrera, María Inés, Capani, Francisco, Otero Losada, Matilde, Pérez Lloret, Santiago
Formato: Artículo
Lenguaje:Inglés
Publicado: Hindawi 2020
Materias:
ASTROCITOS
CELULAS GLIALES
ENFERMEDADES NEUROGENERATIVAS
ENFERMEDAD DE ALZHEIMER
CEREBRO
SEÑALIZACION INTRACELULAR
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/9942
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-9942
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ASTROCITOS
CELULAS GLIALES
ENFERMEDADES NEUROGENERATIVAS
ENFERMEDAD DE ALZHEIMER
CEREBRO
SEÑALIZACION INTRACELULAR
spellingShingle ASTROCITOS
CELULAS GLIALES
ENFERMEDADES NEUROGENERATIVAS
ENFERMEDAD DE ALZHEIMER
CEREBRO
SEÑALIZACION INTRACELULAR
Udovin, Lucas Daniel
Quarracino, Cecilia
Herrera, María Inés
Capani, Francisco
Otero Losada, Matilde
Pérez Lloret, Santiago
Role of astrocytic dysfunction in the pathogenesis of parkinson’s disease animal models from a molecular signaling perspective
topic_facet ASTROCITOS
CELULAS GLIALES
ENFERMEDADES NEUROGENERATIVAS
ENFERMEDAD DE ALZHEIMER
CEREBRO
SEÑALIZACION INTRACELULAR
description Resumen: Despite the fact that astrocytes are the most abundant glial cells, critical for brain function, few studies have dealt with their possible role in neurodegenerative diseases like Parkinson’s disease (PD). This article explores relevant evidence on the involvement of astrocytes in experimental PD neurodegeneration from a molecular signaling perspective. For a long time, astrocytic proliferation was merely considered a byproduct of neuroinflammation, but by the time being, it is clear that astrocytic dysfunction plays a far more important role in PD pathophysiology. Indeed, ongoing experimental evidence suggests the importance of astrocytes and dopaminergic neurons’ cross-linking signaling pathways. The Wnt-1 (wingless-type MMTV integration site family, member 1) pathway regulates several processes including neuron survival, synapse plasticity, and neurogenesis. In PD animal models, Frizzled (Fzd) neuronal receptors’ activation by the Wnt-1 normally released by astrocytes following injuries leads to β-catenin-dependent gene expression, favoring neuron survival and viability. The transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor also participates in experimental PD genesis. Activation of astrocyte TRPV1 receptors by noxious stimuli results in reduced inflammatory response and increased ciliary neurotrophic factor (CNTF) synthesis, which enhances neuronal survival and differentiation. Another major pathway involves IκB kinase (IKK) downregulation by ARL6ip5 (ADP-ribosylation-like factor 6 interacting protein 5, encoded by the cell differentiation-associated, JWA, gene). Typically, IKK releases the proinflammatory NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) molecule from its inhibitor. Therefore, by downregulating NF-κB inhibitor, ARL6ip5 promotes an anti-inflammatory response. The evidence provided by neurotoxin-induced PD animal models guarantees further research on the neuroprotective potential of normalizing astrocyte function in PD.
format Artículo
author Udovin, Lucas Daniel
Quarracino, Cecilia
Herrera, María Inés
Capani, Francisco
Otero Losada, Matilde
Pérez Lloret, Santiago
author_facet Udovin, Lucas Daniel
Quarracino, Cecilia
Herrera, María Inés
Capani, Francisco
Otero Losada, Matilde
Pérez Lloret, Santiago
author_sort Udovin, Lucas Daniel
title Role of astrocytic dysfunction in the pathogenesis of parkinson’s disease animal models from a molecular signaling perspective
title_short Role of astrocytic dysfunction in the pathogenesis of parkinson’s disease animal models from a molecular signaling perspective
title_full Role of astrocytic dysfunction in the pathogenesis of parkinson’s disease animal models from a molecular signaling perspective
title_fullStr Role of astrocytic dysfunction in the pathogenesis of parkinson’s disease animal models from a molecular signaling perspective
title_full_unstemmed Role of astrocytic dysfunction in the pathogenesis of parkinson’s disease animal models from a molecular signaling perspective
title_sort role of astrocytic dysfunction in the pathogenesis of parkinson’s disease animal models from a molecular signaling perspective
publisher Hindawi
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/9942
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