Melatonin as a chronobiotic/cytoprotector : its role in healthy aging

Abstract: Preservation of sleep, a proper nutrition and adequate physical exercise are key elements for healthy aging. Aging causes sleep alterations, and in turn, sleep disturbances lead to numerous pathophysiological changes that accelerates the aging process. In the central nervous system, sleep...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autor principal: Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Publicado: Taylor & Francis 2020
Materias:
MELATONINA
ENVEJECIMIENTO
SUEÑO
INFLAMACION
ENFERMEDAD DE ALZHEIMER
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/9738
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-9738
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MELATONINA
ENVEJECIMIENTO
SUEÑO
INFLAMACION
ENFERMEDAD DE ALZHEIMER
spellingShingle MELATONINA
ENVEJECIMIENTO
SUEÑO
INFLAMACION
ENFERMEDAD DE ALZHEIMER
Cardinali, Daniel Pedro
Melatonin as a chronobiotic/cytoprotector : its role in healthy aging
topic_facet MELATONINA
ENVEJECIMIENTO
SUEÑO
INFLAMACION
ENFERMEDAD DE ALZHEIMER
description Abstract: Preservation of sleep, a proper nutrition and adequate physical exercise are key elements for healthy aging. Aging causes sleep alterations, and in turn, sleep disturbances lead to numerous pathophysiological changes that accelerates the aging process. In the central nervous system, sleep loss impairs the clearance of waste molecules like amyloid-β or tau peptides. Melatonin, a molecule of unusual phylogenetic conservation present in all known aerobic organisms, is effective both as a chronobiotic and a cytoprotective agent to maintain a healthy aging. The late afternoon increase of melatonin “opens the sleep doors” every night and its therapeutic use to preserve slow wave sleep has been demonstrated. Melatonin reverses inflammaging via prevention of insulin resistance, suppression of inflammation and down regulation of proinflammatory cytokines. Melatonin increases the expression of α- and γ-secretase and decreases β-secretase expression. It also inhibits tau phosphorylation. Clinical data support the efficacy of melatonin to treat Alzheimer’s disease, particularly at the early stages of disease. From animal studies the cytoprotective effects of melatonin need high doses to become apparent (i.e. in the 40–100 mg/day range). The potentiality of melatonin as a nutraceutical is discussed.
format Artículo
author Cardinali, Daniel Pedro
author_facet Cardinali, Daniel Pedro
author_sort Cardinali, Daniel Pedro
title Melatonin as a chronobiotic/cytoprotector : its role in healthy aging
title_short Melatonin as a chronobiotic/cytoprotector : its role in healthy aging
title_full Melatonin as a chronobiotic/cytoprotector : its role in healthy aging
title_fullStr Melatonin as a chronobiotic/cytoprotector : its role in healthy aging
title_full_unstemmed Melatonin as a chronobiotic/cytoprotector : its role in healthy aging
title_sort melatonin as a chronobiotic/cytoprotector : its role in healthy aging
publisher Taylor & Francis
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/9738
work_keys_str_mv AT cardinalidanielpedro melatoninasachronobioticcytoprotectoritsroleinhealthyaging
bdutipo_str Repositorios
_version_ 1764820528522067970

Ejemplares similares