The chloride anion as a signalling effector

Abstract: The specific role of the chloride anion (Cl- ) as a signalling effector or second messenger has been increasingly recognized in recent years. It could represent a key factor in the regulation of cellular homeostasis. Changes in intracellular Cl- concentration affect diverse cellular functi...

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Autores principales: Valdivieso, Ángel Gabriel, Santa Coloma, Tomás Antonio
Formato: Artículo
Lenguaje:Inglés
Publicado: Wiley 2020
Materias:
TRANSDUCCION DE SEÑAL
CFTR
ANION CLORURO
INFLAMACION
ESTRES OXIDATIVO
SEÑALIZACION INTRACELULAR
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/9737
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-9737
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic TRANSDUCCION DE SEÑAL
CFTR
ANION CLORURO
INFLAMACION
ESTRES OXIDATIVO
SEÑALIZACION INTRACELULAR
spellingShingle TRANSDUCCION DE SEÑAL
CFTR
ANION CLORURO
INFLAMACION
ESTRES OXIDATIVO
SEÑALIZACION INTRACELULAR
Valdivieso, Ángel Gabriel
Santa Coloma, Tomás Antonio
The chloride anion as a signalling effector
topic_facet TRANSDUCCION DE SEÑAL
CFTR
ANION CLORURO
INFLAMACION
ESTRES OXIDATIVO
SEÑALIZACION INTRACELULAR
description Abstract: The specific role of the chloride anion (Cl- ) as a signalling effector or second messenger has been increasingly recognized in recent years. It could represent a key factor in the regulation of cellular homeostasis. Changes in intracellular Cl- concentration affect diverse cellular functions such as gene and protein expression and activities, post-translational modifications of proteins, cellular volume, cell cycle, cell proliferation and differentiation, membrane potential, reactive oxygen species levels, and intracellular/extracellular pH. Cl- also modulates functions in different organelles, including endosomes, phagosomes, lysosomes, endoplasmic reticulum, and mitochondria. A better knowledge of Cl- signalling could help in understanding the molecular and metabolic changes seen in pathologies with altered Cl- transport or under physiological conditions. Here we review relevant evidence supporting the role of Cl- as a signalling effector.
format Artículo
author Valdivieso, Ángel Gabriel
Santa Coloma, Tomás Antonio
author_facet Valdivieso, Ángel Gabriel
Santa Coloma, Tomás Antonio
author_sort Valdivieso, Ángel Gabriel
title The chloride anion as a signalling effector
title_short The chloride anion as a signalling effector
title_full The chloride anion as a signalling effector
title_fullStr The chloride anion as a signalling effector
title_full_unstemmed The chloride anion as a signalling effector
title_sort chloride anion as a signalling effector
publisher Wiley
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/9737
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AT santacolomatomasantonio thechlorideanionasasignallingeffector
AT valdiviesoangelgabriel chlorideanionasasignallingeffector
AT santacolomatomasantonio chlorideanionasasignallingeffector
bdutipo_str Repositorios
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