Chronobiological theories of mood disorder

Abstract: Major depressive disorder (MDD) remains the most prevalent mental disorder and a leading cause of disability, affecting approximately 100 million adults worldwide. The disorder is characterized by a constellation of symptoms affecting mood, anxiety, neurochemical balance, sleep patterns, a...

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Autores principales: Zaki, Nevin F. W., Spence, David Warren, BaHammam, Ahmed S., Pandi Perumal, Seithikurippu R., Cardinali, Daniel Pedro, Brown, Gregory M.
Formato: Artículo
Lenguaje:Inglés
Publicado: Springer 2020
Materias:
LUZ
CRONOBIOLOGIA
RITMO CIRCADIANO
DEPRESION
MELATONINA
TRASTORNOS DEL ESTADO DE ANIMO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/9552
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-9552
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic LUZ
CRONOBIOLOGIA
RITMO CIRCADIANO
DEPRESION
MELATONINA
TRASTORNOS DEL ESTADO DE ANIMO
spellingShingle LUZ
CRONOBIOLOGIA
RITMO CIRCADIANO
DEPRESION
MELATONINA
TRASTORNOS DEL ESTADO DE ANIMO
Zaki, Nevin F. W.
Spence, David Warren
BaHammam, Ahmed S.
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Brown, Gregory M.
Chronobiological theories of mood disorder
topic_facet LUZ
CRONOBIOLOGIA
RITMO CIRCADIANO
DEPRESION
MELATONINA
TRASTORNOS DEL ESTADO DE ANIMO
description Abstract: Major depressive disorder (MDD) remains the most prevalent mental disorder and a leading cause of disability, affecting approximately 100 million adults worldwide. The disorder is characterized by a constellation of symptoms affecting mood, anxiety, neurochemical balance, sleep patterns, and circadian and/or seasonal rhythm entrainment. However, the mechanisms underlying the association between chronobiological parameters and depression remain unknown. A PubMed search was conducted to review articles from 1979 to the present, using the following search terms: "chronobiology," "mood," "sleep," and "circadian rhythms." We aimed to synthesize the literature investigating chronobiological theories of mood disorders. Current treatments primarily include tricyclic antidepressants and selective serotonin reuptake inhibitors, which are known to increase extracellular concentrations of monoamine neurotransmitters. However, these antidepressants do not treat the sleep disturbances or circadian and/or seasonal rhythm dysfunctions associated with depressive disorders. Several theories associating sleep and circadian rhythm disturbances with depression have been proposed. Current evidence supports the existence of associations between these, but the direction of causality remains elusive. Given the existence of chronobiological disturbances in depression and evidence regarding their treatment in improving depression, a chronobiological approach, including timely use of light and melatonin agonists, could complement the treatment of MDD.
format Artículo
author Zaki, Nevin F. W.
Spence, David Warren
BaHammam, Ahmed S.
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Brown, Gregory M.
author_facet Zaki, Nevin F. W.
Spence, David Warren
BaHammam, Ahmed S.
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Brown, Gregory M.
author_sort Zaki, Nevin F. W.
title Chronobiological theories of mood disorder
title_short Chronobiological theories of mood disorder
title_full Chronobiological theories of mood disorder
title_fullStr Chronobiological theories of mood disorder
title_full_unstemmed Chronobiological theories of mood disorder
title_sort chronobiological theories of mood disorder
publisher Springer
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/9552
work_keys_str_mv AT zakinevinfw chronobiologicaltheoriesofmooddisorder
AT spencedavidwarren chronobiologicaltheoriesofmooddisorder
AT bahammamahmeds chronobiologicaltheoriesofmooddisorder
AT pandiperumalseithikurippur chronobiologicaltheoriesofmooddisorder
AT cardinalidanielpedro chronobiologicaltheoriesofmooddisorder
AT browngregorym chronobiologicaltheoriesofmooddisorder
bdutipo_str Repositorios
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