Histamine H4 receptor : insights into a potential therapeutic target in breast cancer

Abstract: Breast cancer is the second most common cancer worldwide, and the leading cause of cancer death in women. Several studies underlined the critical role of histamine in breast cancer development and progression. This review addresses the latest evidence regarding the involvement of histami...

Descripción completa

Detalles Bibliográficos
Autores principales: Martinel Lamas, Diego J., Rivera, Elena S., Medina, Vanina Araceli
Formato: Artículo
Lenguaje:Inglés
Publicado: 2020
Materias:
CANCER DE MAMA
HISTAMINA
TRATAMIENTO MEDICO
ONCOLOGIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/9437
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-9437
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic CANCER DE MAMA
HISTAMINA
TRATAMIENTO MEDICO
ONCOLOGIA
spellingShingle CANCER DE MAMA
HISTAMINA
TRATAMIENTO MEDICO
ONCOLOGIA
Martinel Lamas, Diego J.
Rivera, Elena S.
Medina, Vanina Araceli
Histamine H4 receptor : insights into a potential therapeutic target in breast cancer
topic_facet CANCER DE MAMA
HISTAMINA
TRATAMIENTO MEDICO
ONCOLOGIA
description Abstract: Breast cancer is the second most common cancer worldwide, and the leading cause of cancer death in women. Several studies underlined the critical role of histamine in breast cancer development and progression. This review addresses the latest evidence regarding the involvement of histamine and histamine receptors in breast cancer, focusing particularly in the histamine H4 receptor (H4R). Histamine concentration in breast cancer tissues was found to be higher than that in normal tissues of healthy controls by means of an increase in the activity of histidine decarboxylase (HDC), the enzyme involved in histamine production. The expression of H4R in different experimental models and human biopsies, the associated biological responses, as well as the in vivo treatment of experimental tumors with H4R ligands is reviewed. Evidence demonstrates that the H4R exhibits a key role in histamine-mediated biological processes such as cell proliferation, senescence and apoptosis in breast cancer. The polymorphisms of the H4R and HDC genes and their association with breast cancer risk and malignancy reinforce the critical (patho) physiological role of H4R in breast cancer. In addition, H4R agonists display anti-tumor effects in vivo in a triple negative breast cancer model. The findings support the exploitation of the H4R as a molecular target for breast cancer drug development.
format Artículo
author Martinel Lamas, Diego J.
Rivera, Elena S.
Medina, Vanina Araceli
author_facet Martinel Lamas, Diego J.
Rivera, Elena S.
Medina, Vanina Araceli
author_sort Martinel Lamas, Diego J.
title Histamine H4 receptor : insights into a potential therapeutic target in breast cancer
title_short Histamine H4 receptor : insights into a potential therapeutic target in breast cancer
title_full Histamine H4 receptor : insights into a potential therapeutic target in breast cancer
title_fullStr Histamine H4 receptor : insights into a potential therapeutic target in breast cancer
title_full_unstemmed Histamine H4 receptor : insights into a potential therapeutic target in breast cancer
title_sort histamine h4 receptor : insights into a potential therapeutic target in breast cancer
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/9437
work_keys_str_mv AT martinellamasdiegoj histamineh4receptorinsightsintoapotentialtherapeutictargetinbreastcancer
AT riveraelenas histamineh4receptorinsightsintoapotentialtherapeutictargetinbreastcancer
AT medinavaninaaraceli histamineh4receptorinsightsintoapotentialtherapeutictargetinbreastcancer
bdutipo_str Repositorios
_version_ 1764820528003022848

Ejemplares similares