GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2

Abstract: Interleukin 6 (IL6) and tumor necrosis factor contribute to the development of colitis-associated cancer (CAC). We investigated these signaling pathways and the involvement of G protein subunit alpha i1 (GNAI1), GNAI2, and GNAI3 in the development of CAC in mice and humans. GNAI1;3 suppres...

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Autores principales: Li, Zhi-Wei, Sun, Beicheng, Gong, Ting, Guo, Sheng, Zhang, Jianhua, Wang, Junlong, Sugawara, Atsushi, Jiang, Meisheng, Yan, Junjun, Gurary, Alexandra, Zheng, Xin, Gao, Bifeng, Xiao, Shu-Yuan, Chen, Wenlian, Ma, Chi, Farrar, Christine, Zhu, Chenjun, Chan, Owen T. M., Xin, Can, Winnicki, Andrew, Winnicki, John, Tang, Mingxin, Park, Ryan, Winnicki, Mary, Diener, Katrina, Wang, Zhanwei, Liu, Qicai, Chu, Catherine H., Arter, Zhaohui L., Yue, Peibin, Alpert, Lindsay, Hui, George S., Fei, Peiwen, Turkson, James, Yang, Wentian, Wu, Guangyu, Tao, Ailin, Ramos, Joe W., Moisyadi, Stefan, Holcombe, Randall F., Jia, Wei, Birnbaumer, Lutz, Zhou, Xiqiao, Chu, Wen-Ming
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2019
Materias:
CANCER
TUMORES
COLITIS
CARCINOGENESIS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/9271
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina

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