GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2

Abstract: Interleukin 6 (IL6) and tumor necrosis factor contribute to the development of colitis-associated cancer (CAC). We investigated these signaling pathways and the involvement of G protein subunit alpha i1 (GNAI1), GNAI2, and GNAI3 in the development of CAC in mice and humans. GNAI1;3 suppres...

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Detalles Bibliográficos
Autores principales: Li, Zhi-Wei, Sun, Beicheng, Gong, Ting, Guo, Sheng, Zhang, Jianhua, Wang, Junlong, Sugawara, Atsushi, Jiang, Meisheng, Yan, Junjun, Gurary, Alexandra, Zheng, Xin, Gao, Bifeng, Xiao, Shu-Yuan, Chen, Wenlian, Ma, Chi, Farrar, Christine, Zhu, Chenjun, Chan, Owen T. M., Xin, Can, Winnicki, Andrew, Winnicki, John, Tang, Mingxin, Park, Ryan, Winnicki, Mary, Diener, Katrina, Wang, Zhanwei, Liu, Qicai, Chu, Catherine H., Arter, Zhaohui L., Yue, Peibin, Alpert, Lindsay, Hui, George S., Fei, Peiwen, Turkson, James, Yang, Wentian, Wu, Guangyu, Tao, Ailin, Ramos, Joe W., Moisyadi, Stefan, Holcombe, Randall F., Jia, Wei, Birnbaumer, Lutz, Zhou, Xiqiao, Chu, Wen-Ming
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2019
Materias:
CANCER
TUMORES
COLITIS
CARCINOGENESIS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/9271
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-9271
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic CANCER
TUMORES
COLITIS
CARCINOGENESIS
spellingShingle CANCER
TUMORES
COLITIS
CARCINOGENESIS
Li, Zhi-Wei
Sun, Beicheng
Gong, Ting
Guo, Sheng
Zhang, Jianhua
Wang, Junlong
Sugawara, Atsushi
Jiang, Meisheng
Yan, Junjun
Gurary, Alexandra
Zheng, Xin
Gao, Bifeng
Xiao, Shu-Yuan
Chen, Wenlian
Ma, Chi
Farrar, Christine
Zhu, Chenjun
Chan, Owen T. M.
Xin, Can
Winnicki, Andrew
Winnicki, John
Tang, Mingxin
Park, Ryan
Winnicki, Mary
Diener, Katrina
Wang, Zhanwei
Liu, Qicai
Chu, Catherine H.
Arter, Zhaohui L.
Yue, Peibin
Alpert, Lindsay
Hui, George S.
Fei, Peiwen
Turkson, James
Yang, Wentian
Wu, Guangyu
Tao, Ailin
Ramos, Joe W.
Moisyadi, Stefan
Holcombe, Randall F.
Jia, Wei
Birnbaumer, Lutz
Zhou, Xiqiao
Chu, Wen-Ming
GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2
topic_facet CANCER
TUMORES
COLITIS
CARCINOGENESIS
description Abstract: Interleukin 6 (IL6) and tumor necrosis factor contribute to the development of colitis-associated cancer (CAC). We investigated these signaling pathways and the involvement of G protein subunit alpha i1 (GNAI1), GNAI2, and GNAI3 in the development of CAC in mice and humans. GNAI1;3 suppresses DSS-plus-AOM–induced colon tumor development in mice, whereas expression of GNAI2 in CD11c+ cells and IL6 in CD4+/CD11b+ DCs appears to promote these effects. Strategies to induce GNAI1;3, or block GNAI2 and IL6, might be developed for the prevention or therapy of CAC in patients.
format Artículo
author Li, Zhi-Wei
Sun, Beicheng
Gong, Ting
Guo, Sheng
Zhang, Jianhua
Wang, Junlong
Sugawara, Atsushi
Jiang, Meisheng
Yan, Junjun
Gurary, Alexandra
Zheng, Xin
Gao, Bifeng
Xiao, Shu-Yuan
Chen, Wenlian
Ma, Chi
Farrar, Christine
Zhu, Chenjun
Chan, Owen T. M.
Xin, Can
Winnicki, Andrew
Winnicki, John
Tang, Mingxin
Park, Ryan
Winnicki, Mary
Diener, Katrina
Wang, Zhanwei
Liu, Qicai
Chu, Catherine H.
Arter, Zhaohui L.
Yue, Peibin
Alpert, Lindsay
Hui, George S.
Fei, Peiwen
Turkson, James
Yang, Wentian
Wu, Guangyu
Tao, Ailin
Ramos, Joe W.
Moisyadi, Stefan
Holcombe, Randall F.
Jia, Wei
Birnbaumer, Lutz
Zhou, Xiqiao
Chu, Wen-Ming
author_facet Li, Zhi-Wei
Sun, Beicheng
Gong, Ting
Guo, Sheng
Zhang, Jianhua
Wang, Junlong
Sugawara, Atsushi
Jiang, Meisheng
Yan, Junjun
Gurary, Alexandra
Zheng, Xin
Gao, Bifeng
Xiao, Shu-Yuan
Chen, Wenlian
Ma, Chi
Farrar, Christine
Zhu, Chenjun
Chan, Owen T. M.
Xin, Can
Winnicki, Andrew
Winnicki, John
Tang, Mingxin
Park, Ryan
Winnicki, Mary
Diener, Katrina
Wang, Zhanwei
Liu, Qicai
Chu, Catherine H.
Arter, Zhaohui L.
Yue, Peibin
Alpert, Lindsay
Hui, George S.
Fei, Peiwen
Turkson, James
Yang, Wentian
Wu, Guangyu
Tao, Ailin
Ramos, Joe W.
Moisyadi, Stefan
Holcombe, Randall F.
Jia, Wei
Birnbaumer, Lutz
Zhou, Xiqiao
Chu, Wen-Ming
author_sort Li, Zhi-Wei
title GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2
title_short GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2
title_full GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2
title_fullStr GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2
title_full_unstemmed GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2
title_sort gnai1 and gnai3 reduce colitis-associated tumorigenesis in mice by blocking il6 signaling and down-regulating expression of gnai2
publisher Elsevier
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/9271
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