Radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid

Abstract: Radiotherapy is one of the leading treatments for clinical cancer therapy. External beam radiotherapy has been proposed as an adjuvant treatment for patients bearing differentiated thyroid cancer refractory to conventional therapy. Our purpose was to study the combined effect of HDAC inhib...

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Autores principales: Perona, Marina, Thomasz, Lisa, Rossich, Luciano, Rodríguez, Carla, Pisarev, Mario A., Rosemblit, Cinthia, Cremaschi, Graciela A., Dagrosa, María Alejandra, Juvenal, Guillermo J.
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2019
Materias:
CANCER
GLANDULA TIROIDES
ENZIMAS
ADN
RADIOSENSIBILIDAD
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8795
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8795
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic CANCER
GLANDULA TIROIDES
ENZIMAS
ADN
RADIOSENSIBILIDAD
spellingShingle CANCER
GLANDULA TIROIDES
ENZIMAS
ADN
RADIOSENSIBILIDAD
Perona, Marina
Thomasz, Lisa
Rossich, Luciano
Rodríguez, Carla
Pisarev, Mario A.
Rosemblit, Cinthia
Cremaschi, Graciela A.
Dagrosa, María Alejandra
Juvenal, Guillermo J.
Radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid
topic_facet CANCER
GLANDULA TIROIDES
ENZIMAS
ADN
RADIOSENSIBILIDAD
description Abstract: Radiotherapy is one of the leading treatments for clinical cancer therapy. External beam radiotherapy has been proposed as an adjuvant treatment for patients bearing differentiated thyroid cancer refractory to conventional therapy. Our purpose was to study the combined effect of HDAC inhibitors (HDACi) and ionizing irradiation in thyroid cancer cell lines (Nthy-ori 3-1, WRO, TPC-1 and 8505c). HDACi radiosensitized thyroid cancer cells as evidenced by the reduction of survival fraction, whereas they had no effect in the normal cells. HDACi enhanced radiation-induced cell death in WRO cells. Gamma-H2AX foci number increased and persisted long after ionizing exposure in the HDACi-treated cells (WRO and TPC-1). Moreover, the expression of the repair-related gene Ku80 was differentially modulated only in the cancer cells, by the compounds at the protein and/or mRNA levels. We present in vitro evidence that HDACi can enhance the radiosensitivity of human thyroid cancer cells.
format Artículo
author Perona, Marina
Thomasz, Lisa
Rossich, Luciano
Rodríguez, Carla
Pisarev, Mario A.
Rosemblit, Cinthia
Cremaschi, Graciela A.
Dagrosa, María Alejandra
Juvenal, Guillermo J.
author_facet Perona, Marina
Thomasz, Lisa
Rossich, Luciano
Rodríguez, Carla
Pisarev, Mario A.
Rosemblit, Cinthia
Cremaschi, Graciela A.
Dagrosa, María Alejandra
Juvenal, Guillermo J.
author_sort Perona, Marina
title Radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid
title_short Radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid
title_full Radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid
title_fullStr Radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid
title_full_unstemmed Radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid
title_sort radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid
publisher Elsevier
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8795
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