Histamine receptors and cancer pharmacology : an update

Abstract: In the present review, we will discuss the recent advances in the understanding of the role of histamine and histamine receptors in cancer biology. The controversial role of the histaminergic system in different neoplasias including gastric, colorectal, oesophageal, oral, pancreatic, liver...

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Autores principales: Massari, Noelia A., Nicoud, Melisa Beatriz, Medina, Vanina Araceli
Formato: Artículo
Lenguaje:Inglés
Publicado: Wiley 2019
Materias:
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8790
Aporte de:
id I33-R139123456789-8790
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic HISTAMINA
CANCER
TUMORES
MARCADORES BIOLOGICOS
spellingShingle HISTAMINA
CANCER
TUMORES
MARCADORES BIOLOGICOS
Massari, Noelia A.
Nicoud, Melisa Beatriz
Medina, Vanina Araceli
Histamine receptors and cancer pharmacology : an update
topic_facet HISTAMINA
CANCER
TUMORES
MARCADORES BIOLOGICOS
description Abstract: In the present review, we will discuss the recent advances in the understanding of the role of histamine and histamine receptors in cancer biology. The controversial role of the histaminergic system in different neoplasias including gastric, colorectal, oesophageal, oral, pancreatic, liver, lung, skin, blood and breast cancers will be reviewed. The expression of histamine receptor subtypes, with special emphasis on the histamine H4 receptor, in different cell lines and human tumours, the signal transduction pathways and the associated biological responses as well as the in vivo treatment of experimental tumours with pharmacological ligands will be described. The presented evidence demonstrates that histamine regulates cancer-associated biological processes during cancer development in multiple cell types, including neoplastic cells and cells in the tumour micro-environment. The outcome will depend on tumour cell type, the level of expression of histamine receptors, signal transduction associated with these receptors, tumour micro-environment and histamine metabolism, reinforcing the complexity of cancer disease. Findings show the pivotal role of H4 receptors in the development and progression of many types of cancers, and considering its immunomodulatory properties, the H4 receptor appears to be the most promising molecular therapeutic target for cancer treatment within the histamine receptor family. Furthermore, the H4 receptor is differentially expressed in tumours compared with normal tissues, and in most cancer types in which data are available, H4 receptor expression is associated with clinicopathological characteristics, suggesting that H4 receptors might represent a novel cancer biomarker.
format Artículo
author Massari, Noelia A.
Nicoud, Melisa Beatriz
Medina, Vanina Araceli
author_facet Massari, Noelia A.
Nicoud, Melisa Beatriz
Medina, Vanina Araceli
author_sort Massari, Noelia A.
title Histamine receptors and cancer pharmacology : an update
title_short Histamine receptors and cancer pharmacology : an update
title_full Histamine receptors and cancer pharmacology : an update
title_fullStr Histamine receptors and cancer pharmacology : an update
title_full_unstemmed Histamine receptors and cancer pharmacology : an update
title_sort histamine receptors and cancer pharmacology : an update
publisher Wiley
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8790
work_keys_str_mv AT massarinoeliaa histaminereceptorsandcancerpharmacologyanupdate
AT nicoudmelisabeatriz histaminereceptorsandcancerpharmacologyanupdate
AT medinavaninaaraceli histaminereceptorsandcancerpharmacologyanupdate
bdutipo_str Repositorios
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