Histamine receptors and cancer pharmacology : an update
Abstract: In the present review, we will discuss the recent advances in the understanding of the role of histamine and histamine receptors in cancer biology. The controversial role of the histaminergic system in different neoplasias including gastric, colorectal, oesophageal, oral, pancreatic, liver...
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Formato: | Artículo |
Lenguaje: | Inglés |
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Wiley
2019
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Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/8790 |
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I33-R139123456789-8790 |
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institution |
Universidad Católica Argentina |
institution_str |
I-33 |
repository_str |
R-139 |
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Repositorio Institucional de la Universidad Católica Argentina (UCA) |
language |
Inglés |
topic |
HISTAMINA CANCER TUMORES MARCADORES BIOLOGICOS |
spellingShingle |
HISTAMINA CANCER TUMORES MARCADORES BIOLOGICOS Massari, Noelia A. Nicoud, Melisa Beatriz Medina, Vanina Araceli Histamine receptors and cancer pharmacology : an update |
topic_facet |
HISTAMINA CANCER TUMORES MARCADORES BIOLOGICOS |
description |
Abstract: In the present review, we will discuss the recent advances in the understanding of the role of histamine and histamine receptors in cancer biology. The controversial role of the histaminergic system in different neoplasias including gastric, colorectal, oesophageal, oral, pancreatic, liver, lung, skin, blood and breast cancers will be reviewed. The expression of histamine receptor subtypes, with special emphasis on the histamine H4 receptor, in different cell lines and human tumours, the signal transduction pathways and the associated biological responses as well as the in vivo treatment of experimental tumours with pharmacological ligands will be described. The presented evidence demonstrates that histamine regulates cancer-associated biological processes during cancer development in multiple cell types, including neoplastic cells and cells in the tumour micro-environment. The outcome will depend on tumour cell type, the level of expression of histamine receptors, signal transduction associated with these receptors, tumour micro-environment and histamine metabolism, reinforcing the complexity of cancer disease. Findings show the pivotal role of H4 receptors in the development and progression of many types of cancers, and considering its immunomodulatory properties, the H4 receptor appears to be the most promising molecular therapeutic target for cancer treatment within the histamine receptor family. Furthermore, the H4 receptor is differentially expressed in tumours compared with normal tissues, and in most cancer types in which data are available, H4 receptor expression is associated with clinicopathological characteristics, suggesting that H4 receptors might represent a novel cancer biomarker. |
format |
Artículo |
author |
Massari, Noelia A. Nicoud, Melisa Beatriz Medina, Vanina Araceli |
author_facet |
Massari, Noelia A. Nicoud, Melisa Beatriz Medina, Vanina Araceli |
author_sort |
Massari, Noelia A. |
title |
Histamine receptors and cancer pharmacology : an update |
title_short |
Histamine receptors and cancer pharmacology : an update |
title_full |
Histamine receptors and cancer pharmacology : an update |
title_fullStr |
Histamine receptors and cancer pharmacology : an update |
title_full_unstemmed |
Histamine receptors and cancer pharmacology : an update |
title_sort |
histamine receptors and cancer pharmacology : an update |
publisher |
Wiley |
publishDate |
2019 |
url |
https://repositorio.uca.edu.ar/handle/123456789/8790 |
work_keys_str_mv |
AT massarinoeliaa histaminereceptorsandcancerpharmacologyanupdate AT nicoudmelisabeatriz histaminereceptorsandcancerpharmacologyanupdate AT medinavaninaaraceli histaminereceptorsandcancerpharmacologyanupdate |
bdutipo_str |
Repositorios |
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