Chaperoning α7 neuronal nicotinic acetylcholine receptors

Abstract: The α7 subtype of nicotinic acetylcholine receptors (AChRs) is one of the most abundant members of the Cys-loop family of receptors present in the central nervous system. It participates in various physiological processes and has received much attention as a potential therapeutic target fo...

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Detalles Bibliográficos
Autores principales: Vallés, Ana Sofía, Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier B.V. 2019
Materias:
RECEPTORES
PROTEINAS
MEMBRANAS CELULARES
RIC-3
NEUROBIOLOGIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8768
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8768
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic RECEPTORES
PROTEINAS
MEMBRANAS CELULARES
RIC-3
NEUROBIOLOGIA
spellingShingle RECEPTORES
PROTEINAS
MEMBRANAS CELULARES
RIC-3
NEUROBIOLOGIA
Vallés, Ana Sofía
Barrantes, Francisco José
Chaperoning α7 neuronal nicotinic acetylcholine receptors
topic_facet RECEPTORES
PROTEINAS
MEMBRANAS CELULARES
RIC-3
NEUROBIOLOGIA
description Abstract: The α7 subtype of nicotinic acetylcholine receptors (AChRs) is one of the most abundant members of the Cys-loop family of receptors present in the central nervous system. It participates in various physiological processes and has received much attention as a potential therapeutic target for a variety of pathologies. The importance of understanding the mechanisms controlling AChR assembly and cell-surface delivery lies in the fact that these two processes are key to determining the functional pool of receptors actively engaged in synaptic transmission. Here we review recent studies showing that RIC-3, a protein originally identified in the worm Caenorhabditis elegans, modulates the expression of α7 AChRs in a subtype-specific manner. Potentiation of AChR expression by post-transcriptional events is also critically assessed.
format Artículo
author Vallés, Ana Sofía
Barrantes, Francisco José
author_facet Vallés, Ana Sofía
Barrantes, Francisco José
author_sort Vallés, Ana Sofía
title Chaperoning α7 neuronal nicotinic acetylcholine receptors
title_short Chaperoning α7 neuronal nicotinic acetylcholine receptors
title_full Chaperoning α7 neuronal nicotinic acetylcholine receptors
title_fullStr Chaperoning α7 neuronal nicotinic acetylcholine receptors
title_full_unstemmed Chaperoning α7 neuronal nicotinic acetylcholine receptors
title_sort chaperoning α7 neuronal nicotinic acetylcholine receptors
publisher Elsevier B.V.
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8768
work_keys_str_mv AT vallesanasofia chaperoninga7neuronalnicotinicacetylcholinereceptors
AT barrantesfranciscojose chaperoninga7neuronalnicotinicacetylcholinereceptors
bdutipo_str Repositorios
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