TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice

Abstract: Canonical transient receptor potential (TRPC) channels constitute a family of cation channels that exhibit a regional and cell-specific expression pattern throughout the brain. It has been reported previously that TRPC3 channels are effectors of the brain-derived neurotrophic factor (BDNF)...

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Detalles Bibliográficos
Autores principales: Phelan, Kevin D., Shwe, U Thaung, Cozart, Michael A., Wu, Hong, Mock, Matthew M., Abramowitz, Joel, Birnbaumer, Lutz, Zheng, Fang
Formato: Artículo
Lenguaje:Inglés
Publicado: Wiley 2019
Materias:
ELECTROENCEFALOGRAFIA
NEURONAS
ANALISIS ESPECTRAL
SISTEMA NERVIOSO
MEDICAMENTOS
EPILEPSIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8738
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
Descripción
Sumario:Abstract: Canonical transient receptor potential (TRPC) channels constitute a family of cation channels that exhibit a regional and cell-specific expression pattern throughout the brain. It has been reported previously that TRPC3 channels are effectors of the brain-derived neurotrophic factor (BDNF)/trkB signaling pathway. Given the long postulated role of BDNF in epileptogenesis, TRPC3 channels may be a critical component in the underlying pathophysiology of seizure and epilepsy. In this study, we investigated the precise role of TRPC3 channels in pilocarpine-induced status epilepticus (SE).

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