Phylogenetic conservation of protein–lipid motifs in pentameric ligand-gated ion channels

Abstract: Using the crosstalk between the nicotinic acetylcholine receptor (nAChR) and its lipid microenvironment as a paradigm, this short overviewanalyzes the occurrence of structuralmotifswhich appear not only to be conserved within the nAChR family and contemporary eukaryotic members of the pen...

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Autor principal: Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier B.V. 2019
Materias:
MEDICINA
RECEPTORES
PROTEINAS
LIPIDOS
CANALES IONICOS
COLESTEROL
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8736
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8736
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MEDICINA
RECEPTORES
PROTEINAS
LIPIDOS
CANALES IONICOS
COLESTEROL
spellingShingle MEDICINA
RECEPTORES
PROTEINAS
LIPIDOS
CANALES IONICOS
COLESTEROL
Barrantes, Francisco José
Phylogenetic conservation of protein–lipid motifs in pentameric ligand-gated ion channels
topic_facet MEDICINA
RECEPTORES
PROTEINAS
LIPIDOS
CANALES IONICOS
COLESTEROL
description Abstract: Using the crosstalk between the nicotinic acetylcholine receptor (nAChR) and its lipid microenvironment as a paradigm, this short overviewanalyzes the occurrence of structuralmotifswhich appear not only to be conserved within the nAChR family and contemporary eukaryotic members of the pentameric ligand-gated ion channel (pLGIC) superfamily, but also extend to prokaryotic homologues found in bacteria. The evolutionarily conserved design ismanifested in: 1) the concentric three-ring architecture of the transmembrane region, 2) the occurrence in this region of distinct lipid consensusmotifs in prokaryotic and eukaryotic pLGIC and 3) the key participation of the outer TM4 ring in conveying the influence of the lipidmembrane environment to themiddle TM1–TM3 ring and this, in turn, to the inner TM2 channel-lining ring, which determines the ion selectivity of the channel. The preservation of these constant structural–functional features throughout such a long phylogenetic span likely points to the successful gain-of-function conferred by their early acquisition. This article is part of a Special Issue entitled: Lipid–protein interactions.
format Artículo
author Barrantes, Francisco José
author_facet Barrantes, Francisco José
author_sort Barrantes, Francisco José
title Phylogenetic conservation of protein–lipid motifs in pentameric ligand-gated ion channels
title_short Phylogenetic conservation of protein–lipid motifs in pentameric ligand-gated ion channels
title_full Phylogenetic conservation of protein–lipid motifs in pentameric ligand-gated ion channels
title_fullStr Phylogenetic conservation of protein–lipid motifs in pentameric ligand-gated ion channels
title_full_unstemmed Phylogenetic conservation of protein–lipid motifs in pentameric ligand-gated ion channels
title_sort phylogenetic conservation of protein–lipid motifs in pentameric ligand-gated ion channels
publisher Elsevier B.V.
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8736
work_keys_str_mv AT barrantesfranciscojose phylogeneticconservationofproteinlipidmotifsinpentamericligandgatedionchannels
bdutipo_str Repositorios
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