99mTc-radiolabeled TPGS nanomicelles outperform 99mTc-sestamibi as breast cancer imaging agent

Abstract: D- α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) is a Food and Drug Administration (FDA) approved biomaterial that can form nanosized micelles in aqueous solution. TPGS micelles stand as an interesting system to perform drug delivery as they can carry lipophilic drugs and overcome...

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Detalles Bibliográficos
Autores principales: Tesan, Fiorella C., Nicoud, Melisa Beatriz, Núñez, Mariel, Medina, Vanina Araceli, Chiappetta, Diego A., Salgueiro, María J.
Formato: Artículo
Lenguaje:Inglés
Publicado: The Wiley Hindawi Partnership 2019
Materias:
MEDICINA
CANCER
ONCOLOGIA
DIAGNOSTICO POR IMAGEN
BIOMATERIALES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8698
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8698
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MEDICINA
CANCER
ONCOLOGIA
DIAGNOSTICO POR IMAGEN
BIOMATERIALES
spellingShingle MEDICINA
CANCER
ONCOLOGIA
DIAGNOSTICO POR IMAGEN
BIOMATERIALES
Tesan, Fiorella C.
Nicoud, Melisa Beatriz
Núñez, Mariel
Medina, Vanina Araceli
Chiappetta, Diego A.
Salgueiro, María J.
99mTc-radiolabeled TPGS nanomicelles outperform 99mTc-sestamibi as breast cancer imaging agent
topic_facet MEDICINA
CANCER
ONCOLOGIA
DIAGNOSTICO POR IMAGEN
BIOMATERIALES
description Abstract: D- α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) is a Food and Drug Administration (FDA) approved biomaterial that can form nanosized micelles in aqueous solution. TPGS micelles stand as an interesting system to perform drug delivery as they can carry lipophilic drugs and overcome P glycoprotein efflux as well. Berefore, TPGS micelles combined with other copolymers have been reported in many cancer research studies as a carrier for therapeutic drugs. Their ability to reach tumoral tissue can also be exploited to develop imaging agents with diagnostic application. A radiolabeling method with 99mTc for TPGS nanosized micelles and their biodistribution in a healthy animal model as well as their pharmacokinetics and radiolabeling stability in vivo was previously reported. The aim of this work was to evaluate the performance of this radioactive probe as a diagnostic imaging agent compared to routinely available SPECTradiopharmaceutical, 99mTc-sestamibi. A small field of view gamma camera was used for scintigraphy studies using radiolabeled TPGS micelles in two animal models of breast cancer: syngeneic 4T1 murine cell line (injected in BALB/c mice) and chemically NMU-induced (Sprague-Dawley rats). Ex vivo radioactivity accumulation in organs of interest was measured by a solid scintillation counter, and a semiquantitative analysis was performed over acquired images as well. Results showed an absence of tumoral visualization in 4T1 model for both radioactive probes by gamma camera imaging. On the contrary, NMU-induced tumors had a clear tumor visualization by scintigraphy. A higher tumor/background ratio and more homogeneous uptake were found for radiolabeled TPGS micelles compared to 99mTc-sestamibi. In conclusion, 99mTc-radiolabeled TPGS micelles might be a potential SPECT imaging probe for diagnostic purposes.
format Artículo
author Tesan, Fiorella C.
Nicoud, Melisa Beatriz
Núñez, Mariel
Medina, Vanina Araceli
Chiappetta, Diego A.
Salgueiro, María J.
author_facet Tesan, Fiorella C.
Nicoud, Melisa Beatriz
Núñez, Mariel
Medina, Vanina Araceli
Chiappetta, Diego A.
Salgueiro, María J.
author_sort Tesan, Fiorella C.
title 99mTc-radiolabeled TPGS nanomicelles outperform 99mTc-sestamibi as breast cancer imaging agent
title_short 99mTc-radiolabeled TPGS nanomicelles outperform 99mTc-sestamibi as breast cancer imaging agent
title_full 99mTc-radiolabeled TPGS nanomicelles outperform 99mTc-sestamibi as breast cancer imaging agent
title_fullStr 99mTc-radiolabeled TPGS nanomicelles outperform 99mTc-sestamibi as breast cancer imaging agent
title_full_unstemmed 99mTc-radiolabeled TPGS nanomicelles outperform 99mTc-sestamibi as breast cancer imaging agent
title_sort 99mtc-radiolabeled tpgs nanomicelles outperform 99mtc-sestamibi as breast cancer imaging agent
publisher The Wiley Hindawi Partnership
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8698
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