Pathophysiological role of histamine H4 receptor in cancer : therapeutic implications

Abstract: Cancer is a leading cause of death in both developed and developing countries. Although advances in cancer research lead to improved anti-neoplastic therapies, they continue to have unfavorable outcomes, including poor response and severe toxicity. Thus, the challenge for the new therap...

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Autores principales: Nicoud, Melisa Beatriz, Formoso, Karina, Medina, Vanina Araceli
Formato: Artículo
Lenguaje:Inglés
Publicado: Frontiers 2019
Materias:
MEDICINA
CANCER
RECEPTORES
HISTAMINA
MELANOMA
TRATAMIENTO MEDICO
ONCOLOGIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8697
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8697
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MEDICINA
CANCER
RECEPTORES
HISTAMINA
MELANOMA
TRATAMIENTO MEDICO
ONCOLOGIA
spellingShingle MEDICINA
CANCER
RECEPTORES
HISTAMINA
MELANOMA
TRATAMIENTO MEDICO
ONCOLOGIA
Nicoud, Melisa Beatriz
Formoso, Karina
Medina, Vanina Araceli
Pathophysiological role of histamine H4 receptor in cancer : therapeutic implications
topic_facet MEDICINA
CANCER
RECEPTORES
HISTAMINA
MELANOMA
TRATAMIENTO MEDICO
ONCOLOGIA
description Abstract: Cancer is a leading cause of death in both developed and developing countries. Although advances in cancer research lead to improved anti-neoplastic therapies, they continue to have unfavorable outcomes, including poor response and severe toxicity. Thus, the challenge for the new therapeutic approaches is to increase antitumor efficacy by targeting different molecules encompassed in the tumor and its microenvironment, as well as their specific interactions. The histamine H4 receptor (H4R) is the last discovered histamine receptor subtype and it modulates important immune functions in innate and in adaptive immune responses. Several ligands have been developed and some of them are being used in clinical trials for immune disorders with promising results. When searched in The Cancer Genome Atlas (TCGA) database, human H4R gene was found to be expressed in bladder cancer, kidney cancer, breast cancer, gastrointestinal cancers, lung cancer, endometrial cancer, and skin cancer. In the present work, we aimed to briefly summarize current knowledge in H4R’s pharmacology and in the clinical use of H4R ligands before focusing on recent data reporting the expression of H4R and its pathophysiological role in cancer, representing a potential molecular target for cancer therapeutics. H4R gene and protein expression in different types of cancers compared with normal tissue as well as its relationship with patient prognosis in terms of survival will be described.
format Artículo
author Nicoud, Melisa Beatriz
Formoso, Karina
Medina, Vanina Araceli
author_facet Nicoud, Melisa Beatriz
Formoso, Karina
Medina, Vanina Araceli
author_sort Nicoud, Melisa Beatriz
title Pathophysiological role of histamine H4 receptor in cancer : therapeutic implications
title_short Pathophysiological role of histamine H4 receptor in cancer : therapeutic implications
title_full Pathophysiological role of histamine H4 receptor in cancer : therapeutic implications
title_fullStr Pathophysiological role of histamine H4 receptor in cancer : therapeutic implications
title_full_unstemmed Pathophysiological role of histamine H4 receptor in cancer : therapeutic implications
title_sort pathophysiological role of histamine h4 receptor in cancer : therapeutic implications
publisher Frontiers
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8697
work_keys_str_mv AT nicoudmelisabeatriz pathophysiologicalroleofhistamineh4receptorincancertherapeuticimplications
AT formosokarina pathophysiologicalroleofhistamineh4receptorincancertherapeuticimplications
AT medinavaninaaraceli pathophysiologicalroleofhistamineh4receptorincancertherapeuticimplications
bdutipo_str Repositorios
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