Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response

Abstract: Chronic stress is known to promote inflammatory bowel disease (IBD), but the underlying mechanism remains largely unresolved. Here, we found chronic stress to sensitize mice to dextran sulfate sodium (DSS)-induced colitis; to increase the infiltration of B cells, neutrophils, and proinflam...

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Autores principales: Gao, Xinghua, Cao, Qiuhua, Cheng, Yan, Zhao, Dandan, Wang, Zhuo, Yang, Hongbao, Wu, Qijin, You, Linjun, Wang, Yue, Lin, Yanting, Li, Xianjing, Wang, Yun, Bian, Jin-Song, Sun, Dongdong, Kong, Lingyi, Birnbaumer, Lutz, Yang, Yong
Formato: Artículo
Lenguaje:Inglés
Publicado: National Academy of Sciences 2019
Materias:
ESTRES
COLITIS
MICROORGANISMOS
SISTEMA INMUNOLOGICO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8696
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8696
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ESTRES
COLITIS
MICROORGANISMOS
SISTEMA INMUNOLOGICO
spellingShingle ESTRES
COLITIS
MICROORGANISMOS
SISTEMA INMUNOLOGICO
Gao, Xinghua
Cao, Qiuhua
Cheng, Yan
Zhao, Dandan
Wang, Zhuo
Yang, Hongbao
Wu, Qijin
You, Linjun
Wang, Yue
Lin, Yanting
Li, Xianjing
Wang, Yun
Bian, Jin-Song
Sun, Dongdong
Kong, Lingyi
Birnbaumer, Lutz
Yang, Yong
Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response
topic_facet ESTRES
COLITIS
MICROORGANISMOS
SISTEMA INMUNOLOGICO
description Abstract: Chronic stress is known to promote inflammatory bowel disease (IBD), but the underlying mechanism remains largely unresolved. Here, we found chronic stress to sensitize mice to dextran sulfate sodium (DSS)-induced colitis; to increase the infiltration of B cells, neutrophils, and proinflammatory ly6Chi macrophages in colonic lamina propria; and to present with decreased thymus and mesenteric lymph node (MLN) coefficients. Circulating total white blood cells were significantly increased after stress, and the proportion of MLN-associated immune cells were largely changed. Results showed a marked activation of IL-6/STAT3 signaling by stress. The detrimental action of stress was not terminated in IL-6-/- mice. Interestingly, the composition of gut microbiota was dramatically changed after stress, with expansion of inflammation-promoting bacteria. Furthermore, results showed stress-induced deficient expression of mucin-2 and lysozyme, which may contribute to the disorder of gut microbiota. Of note is that, in the case of cohousing, the stress-induced immune reaction and decreased body weight were abrogated, and transferred gut microbiota from stressed mice to control mice was sufficient to facilitate DSS-induced colitis. The important role of gut microbiota was further reinforced by broad-spectrum antibiotic treatment. Taken together, our results reveal that chronic stress disturbs gut microbiota, triggering immune system response and facilitating DSS-induced colitis.
format Artículo
author Gao, Xinghua
Cao, Qiuhua
Cheng, Yan
Zhao, Dandan
Wang, Zhuo
Yang, Hongbao
Wu, Qijin
You, Linjun
Wang, Yue
Lin, Yanting
Li, Xianjing
Wang, Yun
Bian, Jin-Song
Sun, Dongdong
Kong, Lingyi
Birnbaumer, Lutz
Yang, Yong
author_facet Gao, Xinghua
Cao, Qiuhua
Cheng, Yan
Zhao, Dandan
Wang, Zhuo
Yang, Hongbao
Wu, Qijin
You, Linjun
Wang, Yue
Lin, Yanting
Li, Xianjing
Wang, Yun
Bian, Jin-Song
Sun, Dongdong
Kong, Lingyi
Birnbaumer, Lutz
Yang, Yong
author_sort Gao, Xinghua
title Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response
title_short Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response
title_full Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response
title_fullStr Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response
title_full_unstemmed Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response
title_sort chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response
publisher National Academy of Sciences
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8696
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