Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens

Abstract: Dopamine input to the dorsal and ventral striatum originates from separate populations of midbrain neurons. Despite differences in afferent inputs and behavioral output, little is known about how dopamine release is encoded by dopamine receptors on medium spiny neurons (MSNs) across striat...

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Detalles Bibliográficos
Autores principales: Marcott, Pamela F., Gong, Sheng, Donthamsetti, Prashant, Grinnell, Steven G., Nelson, Melissa N., Newman, Amy H., Birnbaumer, Lutz, Martemyanov, Kirill A., Javitch, Jonathan A., Ford, Christopher P.
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier (Cell Press) 2019
Materias:
DOPAMINA
ESQUIZOFRENIA
GANGLIOS
CEREBRO
ADICCION
COCAINA
NEUROTRANSMISORES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8695
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8695
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic DOPAMINA
ESQUIZOFRENIA
GANGLIOS
CEREBRO
ADICCION
COCAINA
NEUROTRANSMISORES
spellingShingle DOPAMINA
ESQUIZOFRENIA
GANGLIOS
CEREBRO
ADICCION
COCAINA
NEUROTRANSMISORES
Marcott, Pamela F.
Gong, Sheng
Donthamsetti, Prashant
Grinnell, Steven G.
Nelson, Melissa N.
Newman, Amy H.
Birnbaumer, Lutz
Martemyanov, Kirill A.
Javitch, Jonathan A.
Ford, Christopher P.
Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens
topic_facet DOPAMINA
ESQUIZOFRENIA
GANGLIOS
CEREBRO
ADICCION
COCAINA
NEUROTRANSMISORES
description Abstract: Dopamine input to the dorsal and ventral striatum originates from separate populations of midbrain neurons. Despite differences in afferent inputs and behavioral output, little is known about how dopamine release is encoded by dopamine receptors on medium spiny neurons (MSNs) across striatal subregions. Here we examined the activation of D2 receptors following the synaptic release of dopamine in the dorsal striatum (DStr) and nucleus accumbens (NAc) shell. We found that D2 receptor-mediated synaptic currents were slower in the NAc and this difference occurred at the level of D2-receptor signaling. As a result of preferential coupling to Gαo, we also found that D2 receptors in MSNs demonstrated higher sensitivity for dopamine in the NAc. The higher sensitivity in the NAc was eliminated following cocaine exposure. These results identify differences in the sensitivity and timing of D2-receptor signaling across the striatum that influence how nigrostriatal and mesolimbic signals are encoded across these circuits.
format Artículo
author Marcott, Pamela F.
Gong, Sheng
Donthamsetti, Prashant
Grinnell, Steven G.
Nelson, Melissa N.
Newman, Amy H.
Birnbaumer, Lutz
Martemyanov, Kirill A.
Javitch, Jonathan A.
Ford, Christopher P.
author_facet Marcott, Pamela F.
Gong, Sheng
Donthamsetti, Prashant
Grinnell, Steven G.
Nelson, Melissa N.
Newman, Amy H.
Birnbaumer, Lutz
Martemyanov, Kirill A.
Javitch, Jonathan A.
Ford, Christopher P.
author_sort Marcott, Pamela F.
title Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens
title_short Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens
title_full Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens
title_fullStr Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens
title_full_unstemmed Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens
title_sort regional heterogeneity of d2-receptor signaling in the dorsal striatum and nucleus accumbens
publisher Elsevier (Cell Press)
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8695
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