Gαi proteins are indispensable for hearing

Abstract: From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of Gαi3 for...

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Detalles Bibliográficos
Autores principales: Beer-Hammer, Sandra, Lee, Sze Chim, Mauriac, Stephanie A., Leiss, Veronika, Groh, Isabel A. M., Novakovic, Ana, Piekorz, Roland P., Bucher, Kirsten, Chen, Chengfang, Ni, Kun, Singer, Wibke, Harasztosi, Csaba, Schimmang, Thomas, Zimmermann, Ulrike, Pfeffer, Klaus, Birnbaumer, Lutz, Forge, Andrew, Montcouquiol, Mireille, Knipper, Marlies, Nürnberg, Bernd, Rüttiger, Lukas
Formato: Artículo
Lenguaje:Inglés
Publicado: 2019
Materias:
GENES
AUDICION
PROTEINAS
SORDERA
PERDIDA AUDITIVA
MODIFICIACION GENETICA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8692
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
Descripción
Sumario:Abstract: From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of Gαi3 for asymmetric migration of the kinocilium as well as the orientation and shape of the stereociliary ("hair") bundle, a requirement for the progression of mature hearing. We found that the lack of Gαi3 impairs stereociliary elongation and hair bundle shape in high-frequency cochlear regions, linked to elevated hearing thresholds for high-frequency sound. How these morphological defects translate into hearing phenotypes is not clear.

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