Gαi proteins are indispensable for hearing

Abstract: From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of Gαi3 for...

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Autores principales: Beer-Hammer, Sandra, Lee, Sze Chim, Mauriac, Stephanie A., Leiss, Veronika, Groh, Isabel A. M., Novakovic, Ana, Piekorz, Roland P., Bucher, Kirsten, Chen, Chengfang, Ni, Kun, Singer, Wibke, Harasztosi, Csaba, Schimmang, Thomas, Zimmermann, Ulrike, Pfeffer, Klaus, Birnbaumer, Lutz, Forge, Andrew, Montcouquiol, Mireille, Knipper, Marlies, Nürnberg, Bernd, Rüttiger, Lukas
Formato: Artículo
Lenguaje:Inglés
Publicado: 2019
Materias:
GENES
AUDICION
PROTEINAS
SORDERA
PERDIDA AUDITIVA
MODIFICIACION GENETICA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8692
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8692
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic GENES
AUDICION
PROTEINAS
SORDERA
PERDIDA AUDITIVA
MODIFICIACION GENETICA
spellingShingle GENES
AUDICION
PROTEINAS
SORDERA
PERDIDA AUDITIVA
MODIFICIACION GENETICA
Beer-Hammer, Sandra
Lee, Sze Chim
Mauriac, Stephanie A.
Leiss, Veronika
Groh, Isabel A. M.
Novakovic, Ana
Piekorz, Roland P.
Bucher, Kirsten
Chen, Chengfang
Ni, Kun
Singer, Wibke
Harasztosi, Csaba
Schimmang, Thomas
Zimmermann, Ulrike
Pfeffer, Klaus
Birnbaumer, Lutz
Forge, Andrew
Montcouquiol, Mireille
Knipper, Marlies
Nürnberg, Bernd
Rüttiger, Lukas
Gαi proteins are indispensable for hearing
topic_facet GENES
AUDICION
PROTEINAS
SORDERA
PERDIDA AUDITIVA
MODIFICIACION GENETICA
description Abstract: From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of Gαi3 for asymmetric migration of the kinocilium as well as the orientation and shape of the stereociliary ("hair") bundle, a requirement for the progression of mature hearing. We found that the lack of Gαi3 impairs stereociliary elongation and hair bundle shape in high-frequency cochlear regions, linked to elevated hearing thresholds for high-frequency sound. How these morphological defects translate into hearing phenotypes is not clear.
format Artículo
author Beer-Hammer, Sandra
Lee, Sze Chim
Mauriac, Stephanie A.
Leiss, Veronika
Groh, Isabel A. M.
Novakovic, Ana
Piekorz, Roland P.
Bucher, Kirsten
Chen, Chengfang
Ni, Kun
Singer, Wibke
Harasztosi, Csaba
Schimmang, Thomas
Zimmermann, Ulrike
Pfeffer, Klaus
Birnbaumer, Lutz
Forge, Andrew
Montcouquiol, Mireille
Knipper, Marlies
Nürnberg, Bernd
Rüttiger, Lukas
author_facet Beer-Hammer, Sandra
Lee, Sze Chim
Mauriac, Stephanie A.
Leiss, Veronika
Groh, Isabel A. M.
Novakovic, Ana
Piekorz, Roland P.
Bucher, Kirsten
Chen, Chengfang
Ni, Kun
Singer, Wibke
Harasztosi, Csaba
Schimmang, Thomas
Zimmermann, Ulrike
Pfeffer, Klaus
Birnbaumer, Lutz
Forge, Andrew
Montcouquiol, Mireille
Knipper, Marlies
Nürnberg, Bernd
Rüttiger, Lukas
author_sort Beer-Hammer, Sandra
title Gαi proteins are indispensable for hearing
title_short Gαi proteins are indispensable for hearing
title_full Gαi proteins are indispensable for hearing
title_fullStr Gαi proteins are indispensable for hearing
title_full_unstemmed Gαi proteins are indispensable for hearing
title_sort gαi proteins are indispensable for hearing
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8692
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