The lipid habitats of neurotransmitter receptors in brain

Abstract: Neurotransmitter receptors, the macromolecules specialized in decoding the chemical signals encrypted in the chemical signalingmechanism in the nervous system, occur either at the somatic cell surface of chemically excitable cells or at specialized subcellular structures, the synapses. Syn...

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Detalles Bibliográficos
Autores principales: Borroni, María Virginia, Vallés, Ana Sofía, Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier B.V. 2019
Materias:
SINAPSIS
LIPIDOS
COLESTEROL
NEUROTRANSMISORES
RECEPTORES
PROTEINAS
MEDICINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8691
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8691
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic SINAPSIS
LIPIDOS
COLESTEROL
NEUROTRANSMISORES
RECEPTORES
PROTEINAS
MEDICINA
spellingShingle SINAPSIS
LIPIDOS
COLESTEROL
NEUROTRANSMISORES
RECEPTORES
PROTEINAS
MEDICINA
Borroni, María Virginia
Vallés, Ana Sofía
Barrantes, Francisco José
The lipid habitats of neurotransmitter receptors in brain
topic_facet SINAPSIS
LIPIDOS
COLESTEROL
NEUROTRANSMISORES
RECEPTORES
PROTEINAS
MEDICINA
description Abstract: Neurotransmitter receptors, the macromolecules specialized in decoding the chemical signals encrypted in the chemical signalingmechanism in the nervous system, occur either at the somatic cell surface of chemically excitable cells or at specialized subcellular structures, the synapses. Synapses have lipid compositions distinct from the rest of the cell membrane, suggesting that neurotransmitter receptors and their scaffolding and adaptor protein partners require specific lipid habitats for optimal operation. In this review we discuss some paradigmatic cases of neurotransmitter receptor-lipid interactions, highlighting the chemical nature of the intervening lipid species and providing examples of the receptor mechanisms affected by interaction with lipids. The focus is on the effects of cholesterol, glycerophospholipids and covalent fatty acid acylation on neurotransmitter receptors.We also briefly discuss the role of lipid phase states involving lateral heterogeneities of the host membrane known to modulate membrane transport, protein sorting and signaling. Modulation of neurotransmitter receptors by lipids occurs at multiple levels, affecting a wide span of activities including their trafficking, sorting, stability, residence lifetime at the cell surface, endocytosis, and recycling, among other important functional properties at the synapse.
format Artículo
author Borroni, María Virginia
Vallés, Ana Sofía
Barrantes, Francisco José
author_facet Borroni, María Virginia
Vallés, Ana Sofía
Barrantes, Francisco José
author_sort Borroni, María Virginia
title The lipid habitats of neurotransmitter receptors in brain
title_short The lipid habitats of neurotransmitter receptors in brain
title_full The lipid habitats of neurotransmitter receptors in brain
title_fullStr The lipid habitats of neurotransmitter receptors in brain
title_full_unstemmed The lipid habitats of neurotransmitter receptors in brain
title_sort lipid habitats of neurotransmitter receptors in brain
publisher Elsevier B.V.
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8691
work_keys_str_mv AT borronimariavirginia thelipidhabitatsofneurotransmitterreceptorsinbrain
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