Melanopsin phototransduction is repurposed by ipRGC subtypes to shape the function of distinct visual circuits

Abstract: Melanopsin is expressed in distinct types of intrinsically photosensitive retinal ganglion cells (ipRGCs), which drive behaviors from circadian photoentrainment to contrast detection. A major unanswered question is how the same photopigment, melanopsin, influences such vastly different fun...

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Detalles Bibliográficos
Autores principales: Sonoda, Takuma, Lee, Seul Ki, Birnbaumer, Lutz, Schmidt, Tiffany M.
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier (Cell Press) 2019
Materias:
RETINA
LUZ
COMPORTAMIENTO
GANGLIOS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8690
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8690
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic RETINA
LUZ
COMPORTAMIENTO
GANGLIOS
spellingShingle RETINA
LUZ
COMPORTAMIENTO
GANGLIOS
Sonoda, Takuma
Lee, Seul Ki
Birnbaumer, Lutz
Schmidt, Tiffany M.
Melanopsin phototransduction is repurposed by ipRGC subtypes to shape the function of distinct visual circuits
topic_facet RETINA
LUZ
COMPORTAMIENTO
GANGLIOS
description Abstract: Melanopsin is expressed in distinct types of intrinsically photosensitive retinal ganglion cells (ipRGCs), which drive behaviors from circadian photoentrainment to contrast detection. A major unanswered question is how the same photopigment, melanopsin, influences such vastly different functions. Here we show that melanopsin's role in contrast detection begins in the retina, via direct effects on M4 ipRGC (ON alpha RGC) signaling. This influence persists across an unexpectedly wide range of environmental light levels ranging from starlight to sunlight, which considerably expands the functional reach of melanopsin on visual processing. Moreover, melanopsin increases the excitability of M4 ipRGCs via closure of potassium leak channels, a previously unidentified target of the melanopsin phototransduction cascade. Strikingly, this mechanism is selective for image-forming circuits, as M1 ipRGCs (involved in non-image forming behaviors), exhibit a melanopsin-mediated decrease in excitability. Thus, melanopsin signaling is repurposed by ipRGC subtypes to shape distinct visual behaviors.
format Artículo
author Sonoda, Takuma
Lee, Seul Ki
Birnbaumer, Lutz
Schmidt, Tiffany M.
author_facet Sonoda, Takuma
Lee, Seul Ki
Birnbaumer, Lutz
Schmidt, Tiffany M.
author_sort Sonoda, Takuma
title Melanopsin phototransduction is repurposed by ipRGC subtypes to shape the function of distinct visual circuits
title_short Melanopsin phototransduction is repurposed by ipRGC subtypes to shape the function of distinct visual circuits
title_full Melanopsin phototransduction is repurposed by ipRGC subtypes to shape the function of distinct visual circuits
title_fullStr Melanopsin phototransduction is repurposed by ipRGC subtypes to shape the function of distinct visual circuits
title_full_unstemmed Melanopsin phototransduction is repurposed by ipRGC subtypes to shape the function of distinct visual circuits
title_sort melanopsin phototransduction is repurposed by iprgc subtypes to shape the function of distinct visual circuits
publisher Elsevier (Cell Press)
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8690
work_keys_str_mv AT sonodatakuma melanopsinphototransductionisrepurposedbyiprgcsubtypestoshapethefunctionofdistinctvisualcircuits
AT leeseulki melanopsinphototransductionisrepurposedbyiprgcsubtypestoshapethefunctionofdistinctvisualcircuits
AT birnbaumerlutz melanopsinphototransductionisrepurposedbyiprgcsubtypestoshapethefunctionofdistinctvisualcircuits
AT schmidttiffanym melanopsinphototransductionisrepurposedbyiprgcsubtypestoshapethefunctionofdistinctvisualcircuits
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