Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson’s disease

Abstract: In view of its ability to explain the most frequent motor symptoms of Parkinson’s Disease (PD), degeneration of dopaminergic neurons has been considered one of the disease’s main pathophysiological features. Several studies have shown that neurodegeneration also affects noradrenergic, sero...

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Autores principales: Pérez Lloret, Santiago, Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: Parkinson's Disease Foundation 2019
Materias:
MEDICINA
ENFERMEDAD DE PARKINSON
ENFERMEDADES NEUROGENERATIVAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8688
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8688
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MEDICINA
ENFERMEDAD DE PARKINSON
ENFERMEDADES NEUROGENERATIVAS
spellingShingle MEDICINA
ENFERMEDAD DE PARKINSON
ENFERMEDADES NEUROGENERATIVAS
Pérez Lloret, Santiago
Barrantes, Francisco José
Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson’s disease
topic_facet MEDICINA
ENFERMEDAD DE PARKINSON
ENFERMEDADES NEUROGENERATIVAS
description Abstract: In view of its ability to explain the most frequent motor symptoms of Parkinson’s Disease (PD), degeneration of dopaminergic neurons has been considered one of the disease’s main pathophysiological features. Several studies have shown that neurodegeneration also affects noradrenergic, serotoninergic, cholinergic and other monoaminergic neuronal populations. In this work, the characteristics of cholinergic deficits in PD and their clinical correlates are reviewed. Important neurophysiological processes at the root of several motor and cognitive functions remit to cholinergic neurotransmission at the synaptic, pathway, and circuital levels. The bulk of evidence highlights the link between cholinergic alterations and PD motor symptoms, gait dysfunction, levodopa-induced dyskinesias, cognitive deterioration, psychosis, sleep abnormalities, autonomic dysfunction, and altered olfactory function. The pathophysiology of these symptoms is related to alteration of the cholinergic tone in the striatum and/or to degeneration of cholinergic nuclei, most importantly the nucleus basalis magnocellularis and the pedunculopontine nucleus. Several results suggest the clinical usefulness of antimuscarinic drugs for treating PD motor symptoms and of inhibitors of the enzyme acetylcholinesterase for the treatment of dementia. Data also suggest that these inhibitors and pedunculopontine nucleus deep-brain stimulation might also be effective in preventing falls. Finally, several drugs acting on nicotinic receptors have proved efficacious for treating levodopa-induced dyskinesias and cognitive impairment and as neuroprotective agents in PD animal models. Results in human patients are still lacking.
format Artículo
author Pérez Lloret, Santiago
Barrantes, Francisco José
author_facet Pérez Lloret, Santiago
Barrantes, Francisco José
author_sort Pérez Lloret, Santiago
title Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson’s disease
title_short Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson’s disease
title_full Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson’s disease
title_fullStr Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson’s disease
title_full_unstemmed Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson’s disease
title_sort deficits in cholinergic neurotransmission and their clinical correlates in parkinson’s disease
publisher Parkinson's Disease Foundation
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8688
work_keys_str_mv AT perezlloretsantiago deficitsincholinergicneurotransmissionandtheirclinicalcorrelatesinparkinsonsdisease
AT barrantesfranciscojose deficitsincholinergicneurotransmissionandtheirclinicalcorrelatesinparkinsonsdisease
bdutipo_str Repositorios
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