Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice

Abtract: Go is a member of the pertussis toxin-sensitive Gi/o family. Despite its abundance in the central nervous system, the precise role of Go remains largely unknown compared to other G proteins. In the present study, we explored the functions of Go in the developing cerebellar cortex by deletin...

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Detalles Bibliográficos
Autores principales: Cha, Hye Lim, Choi, Jung-Mi, Oh, Huy-Hyen, Bashyal, Narayan, Kim, Sung-Soo, Birnbaumer, Lutz, Suh-Kim, Haeyoung
Formato: Artículo
Lenguaje:Inglés
Publicado: BMC 2019
Materias:
SISTEMA NERVIOSO CENTRAL
CEREBELO
PROTEINAS
HIPOPLASIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8680
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8680
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic SISTEMA NERVIOSO CENTRAL
CEREBELO
PROTEINAS
HIPOPLASIA
spellingShingle SISTEMA NERVIOSO CENTRAL
CEREBELO
PROTEINAS
HIPOPLASIA
Cha, Hye Lim
Choi, Jung-Mi
Oh, Huy-Hyen
Bashyal, Narayan
Kim, Sung-Soo
Birnbaumer, Lutz
Suh-Kim, Haeyoung
Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice
topic_facet SISTEMA NERVIOSO CENTRAL
CEREBELO
PROTEINAS
HIPOPLASIA
description Abtract: Go is a member of the pertussis toxin-sensitive Gi/o family. Despite its abundance in the central nervous system, the precise role of Go remains largely unknown compared to other G proteins. In the present study, we explored the functions of Go in the developing cerebellar cortex by deleting its gene, Gnao. We performed a histological analysis with cerebellar sections of adult mice by cresyl violet- and immunostaining. Global deletion of Gnao induced cerebellar hypoplasia, reduced arborization of Purkinje cell dendrites, and atrophied Purkinje cell dendritic spines and the terminal boutons of climbing fibers from the inferior olivary nucleus. These results indicate that Go-mediated signaling pathway regulates maturation of presynaptic parallel fibers from granule cells and climbing fibers during the cerebellar cortical development.
format Artículo
author Cha, Hye Lim
Choi, Jung-Mi
Oh, Huy-Hyen
Bashyal, Narayan
Kim, Sung-Soo
Birnbaumer, Lutz
Suh-Kim, Haeyoung
author_facet Cha, Hye Lim
Choi, Jung-Mi
Oh, Huy-Hyen
Bashyal, Narayan
Kim, Sung-Soo
Birnbaumer, Lutz
Suh-Kim, Haeyoung
author_sort Cha, Hye Lim
title Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice
title_short Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice
title_full Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice
title_fullStr Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice
title_full_unstemmed Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice
title_sort deletion of the α subunit of the heterotrimeric go protein impairs cerebellar cortical development in mice
publisher BMC
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8680
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