Non-genomic actions of thyroid hormones regulate the growth and angiogenesis of T cell lymphomas

Abstract: T-cell lymphomas (TCL) are a heterogeneous group of aggressive clinical lymphoproliferative disorders with considerable clinical, morphological, immunophenotypic, and genetic variation, including ~10-15% of all lymphoid neoplasms. Several evidences indicate an important role of the non-neo...

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Autores principales: Cayrol, María Florencia, Sterle, Helena Andrea, Díaz Flaqué, María Celeste, Barreiro Arcos, María Laura, Cremaschi, Graciela A.
Formato: Artículo
Lenguaje:Inglés
Publicado: Frontiers 2019
Materias:
TUMORES
GLANDULA TIROIDES
HORMONAS
CANCER
ANGIOGENESIS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8677
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8677
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic TUMORES
GLANDULA TIROIDES
HORMONAS
CANCER
ANGIOGENESIS
spellingShingle TUMORES
GLANDULA TIROIDES
HORMONAS
CANCER
ANGIOGENESIS
Cayrol, María Florencia
Sterle, Helena Andrea
Díaz Flaqué, María Celeste
Barreiro Arcos, María Laura
Cremaschi, Graciela A.
Non-genomic actions of thyroid hormones regulate the growth and angiogenesis of T cell lymphomas
topic_facet TUMORES
GLANDULA TIROIDES
HORMONAS
CANCER
ANGIOGENESIS
description Abstract: T-cell lymphomas (TCL) are a heterogeneous group of aggressive clinical lymphoproliferative disorders with considerable clinical, morphological, immunophenotypic, and genetic variation, including ~10-15% of all lymphoid neoplasms. Several evidences indicate an important role of the non-neoplastic microenvironment in promoting both tumor growth and dissemination in T cell malignancies. Thus, dysregulation of integrin expression and activity is associated with TCL survival and proliferation. We found that thyroid hormones acting via the integrin αvβ3 receptor are crucial factors in tumor microenvironment (TME) affecting the pathophysiology of TCL cells. Specifically, TH-activated αvβ3 integrin signaling promoted TCL proliferation and induced and an angiogenic program via the up-regulation of the vascular endothelial growth factor (VEGF). This was observed both on different TCL cell lines representing the different subtypes of human hematological malignancy, and in preclinical models of TCL tumors xenotransplanted in immunodeficient mice as well. Moreover, development of solid tumors by inoculation of murine TCLs in syngeneic hyperthyroid mice, showed increased tumor growth along with increased expression of cell cycle regulators. The genomic or pharmacological inhibition of integrin αvβ3 decreased VEGF production, induced TCL cell death and decreased in vivo tumor growth and angiogenesis. Here, we review the non-genomic actions of THs on TCL regulation and their contribution to TCL development and evolution. These actions not only provide novel new insights on the endocrine modulation of TCL, but also provide a potential molecular target for its treatment.
format Artículo
author Cayrol, María Florencia
Sterle, Helena Andrea
Díaz Flaqué, María Celeste
Barreiro Arcos, María Laura
Cremaschi, Graciela A.
author_facet Cayrol, María Florencia
Sterle, Helena Andrea
Díaz Flaqué, María Celeste
Barreiro Arcos, María Laura
Cremaschi, Graciela A.
author_sort Cayrol, María Florencia
title Non-genomic actions of thyroid hormones regulate the growth and angiogenesis of T cell lymphomas
title_short Non-genomic actions of thyroid hormones regulate the growth and angiogenesis of T cell lymphomas
title_full Non-genomic actions of thyroid hormones regulate the growth and angiogenesis of T cell lymphomas
title_fullStr Non-genomic actions of thyroid hormones regulate the growth and angiogenesis of T cell lymphomas
title_full_unstemmed Non-genomic actions of thyroid hormones regulate the growth and angiogenesis of T cell lymphomas
title_sort non-genomic actions of thyroid hormones regulate the growth and angiogenesis of t cell lymphomas
publisher Frontiers
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8677
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AT sterlehelenaandrea nongenomicactionsofthyroidhormonesregulatethegrowthandangiogenesisoftcelllymphomas
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bdutipo_str Repositorios
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