Immunomodulatory role of histamine H4 receptor in breast cancer
BACKGROUND: Although the role of histamine H4 receptor (H4R) in immune cells is being extensively investigated, its immunomodulatory function in cancer is completely unknown. This study aimed to investigate the role of H4R in antitumour immunity in a model of triple-negative breast cancer. METHOD...
| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Español |
| Publicado: |
Springer
2019
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| Materias: | |
| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/8620 |
| Aporte de: |
| id |
I33-R139123456789-8620 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Católica Argentina |
| institution_str |
I-33 |
| repository_str |
R-139 |
| collection |
Repositorio Institucional de la Universidad Católica Argentina (UCA) |
| language |
Español |
| topic |
CANCER DE MAMA HISTAMINA INMUNOLOGIA GENES BIOLOGIA CELULAR |
| spellingShingle |
CANCER DE MAMA HISTAMINA INMUNOLOGIA GENES BIOLOGIA CELULAR Sterle, Helena A. Nicoud, Melisa Beatriz Massari, Noelia A. Táquez Delgado, Mónica Alejandra Herrero Ducloux, María V. Cremaschi, Graciela A. Medina, Vanina Araceli Immunomodulatory role of histamine H4 receptor in breast cancer |
| topic_facet |
CANCER DE MAMA HISTAMINA INMUNOLOGIA GENES BIOLOGIA CELULAR |
| description |
BACKGROUND: Although the role of histamine H4 receptor (H4R) in immune cells is being extensively investigated, its
immunomodulatory function in cancer is completely unknown. This study aimed to investigate the role of H4R in antitumour
immunity in a model of triple-negative breast cancer.
METHODS: We evaluated growth parameters, histological characteristics and the composition of tumour, splenic and tumour
draining lymph node (TDLN) immune subsets, in a syngeneic model, developed orthotopically with 4T1 cells in H4R knockout
(H4R-KO) and wild-type mice.
RESULTS: Mice lacking H4R show reduced tumour size and weight, decreased number of lung metastases and percentage of CD4+
tumour-infiltrating T cells, while exhibiting increased infiltration of NK cells and CD19+ lymphocytes. Likewise, TDLN of H4R-KO mice
show decreased CD4+ T cells and T regulatory cells (CD4+CD25+FoxP3+), and increased percentages of NK cells. Finally, H4R-deficient
mice show decreased Tregs in spleens and non-draining lymph nodes, and a negative correlation between tumour weight and the
percentages of CD4+, CD19+ and NK splenic cells, suggesting that H4R also regulates antitumour immunity at a systemic level.
CONCLUSIONS: This is the first report that demonstrates the participation of H4R in antitumour immunity, suggesting that H4R
could be a target for cancer treatment. |
| format |
Artículo |
| author |
Sterle, Helena A. Nicoud, Melisa Beatriz Massari, Noelia A. Táquez Delgado, Mónica Alejandra Herrero Ducloux, María V. Cremaschi, Graciela A. Medina, Vanina Araceli |
| author_facet |
Sterle, Helena A. Nicoud, Melisa Beatriz Massari, Noelia A. Táquez Delgado, Mónica Alejandra Herrero Ducloux, María V. Cremaschi, Graciela A. Medina, Vanina Araceli |
| author_sort |
Sterle, Helena A. |
| title |
Immunomodulatory role of histamine H4 receptor in breast cancer |
| title_short |
Immunomodulatory role of histamine H4 receptor in breast cancer |
| title_full |
Immunomodulatory role of histamine H4 receptor in breast cancer |
| title_fullStr |
Immunomodulatory role of histamine H4 receptor in breast cancer |
| title_full_unstemmed |
Immunomodulatory role of histamine H4 receptor in breast cancer |
| title_sort |
immunomodulatory role of histamine h4 receptor in breast cancer |
| publisher |
Springer |
| publishDate |
2019 |
| url |
https://repositorio.uca.edu.ar/handle/123456789/8620 |
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Repositorios |
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1764820528359538688 |