Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit

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Abstract: It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment thr...

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Autores principales: Palumbo, María Laura, Di Rosso, María Emilia, Simón, Elías Hugo, González Murano, María Rosa, Genaro, Ana María
Formato: Artículo
Lenguaje:Español
Publicado: Elsevier 2019
Materias:
PROTEINAS
HIPOCAMPO
ESTRES
CITOQUINAS
GANGLIOS LINFATICOS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8592
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8592
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Español
topic PROTEINAS
HIPOCAMPO
ESTRES
CITOQUINAS
GANGLIOS LINFATICOS
spellingShingle PROTEINAS
HIPOCAMPO
ESTRES
CITOQUINAS
GANGLIOS LINFATICOS
Palumbo, María Laura
Di Rosso, María Emilia
Simón, Elías Hugo
González Murano, María Rosa
Genaro, Ana María
Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
topic_facet PROTEINAS
HIPOCAMPO
ESTRES
CITOQUINAS
GANGLIOS LINFATICOS
description Abstract: It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely involved the regulation of the cytokine balance and adult neurogenesis. In addition, recent results suggest that cytokine and neurotrophin expression in the hippocampus displayed similar tendencies as those in the serum. However, if lymphoid cells could be good candidates as peripheral markers of memory impairment have not yet been investigated. For this purpose, we analyzed the spatial memory and the neutrophin and cytokine mRNA levels in lymph nodes and hippocampus in mice submitted to chronic stress treated or not with glatiramer acetate. Results indicated that there was a correlation between the cytokine and neurotrophin mRNA levels in the hippocampus and in the peripheral lymph nodes, and the cognitive performance in BALB/c mice. In particular, our results suggest that altered IFN-γ levels could be used as peripheral biomarker of cognitive deficit and treatment response.
format Artículo
author Palumbo, María Laura
Di Rosso, María Emilia
Simón, Elías Hugo
González Murano, María Rosa
Genaro, Ana María
author_facet Palumbo, María Laura
Di Rosso, María Emilia
Simón, Elías Hugo
González Murano, María Rosa
Genaro, Ana María
author_sort Palumbo, María Laura
title Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_short Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_full Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_fullStr Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_full_unstemmed Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_sort altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
publisher Elsevier
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8592
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AT dirossomariaemilia alteredinterferongexpressioninlymphocytesasapotentialperipheralmarkerofchronicstressinducedcognitivedeficit
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bdutipo_str Repositorios
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