The effects of cholesterol on the nicotinic acetylcholine receptor : an update

Abstract: The pentameric ligand-gated ion channels (pLGIC) constitute a superfamily of neurotransmitter receptors characterized by decoding the neurotransmitter signal into a selective and rapid ion permeation process in the target cell. The lipid environment in which these receptor proteins are emb...

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Autor principal: Barrantes, Francisco José
Formato: Parte de libro
Lenguaje:Inglés
Publicado: Nova 2019
Materias:
NEUROTRANSMISORES
COLESTEROL
PROTEINAS
LIPIDOS
MEMBRANAS CELULARES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8456
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8456
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic NEUROTRANSMISORES
COLESTEROL
PROTEINAS
LIPIDOS
MEMBRANAS CELULARES
spellingShingle NEUROTRANSMISORES
COLESTEROL
PROTEINAS
LIPIDOS
MEMBRANAS CELULARES
Barrantes, Francisco José
The effects of cholesterol on the nicotinic acetylcholine receptor : an update
topic_facet NEUROTRANSMISORES
COLESTEROL
PROTEINAS
LIPIDOS
MEMBRANAS CELULARES
description Abstract: The pentameric ligand-gated ion channels (pLGIC) constitute a superfamily of neurotransmitter receptors characterized by decoding the neurotransmitter signal into a selective and rapid ion permeation process in the target cell. The lipid environment in which these receptor proteins are embedded plays an important role in modulating their topography and function. This occurs at multiple levels, including receptor trafficking, sorting, distribution and residence lifetime at the cell surface, internalization, and recycling. Cholesterol is a major player in these equilibria, via non-selective physical mechanisms operating on the bulk bilayer and through direct binding to the receptor proteins, the latter resulting in more specific influences on function. This review discusses these subjects using the crosstalk between the paradigm pLGIC, the nicotinic acetylcholine receptor, and its lipid milieu, to illustrate the influence of cholesterol on receptor structural and functional properties. The mutual interaction of the two partners is discussed at various levels of organization, from the more general influences on the lipid phase to the more intimate relationship of the sterol with the annular and nonannular sites on the receptor.
format Parte de libro
author Barrantes, Francisco José
author_facet Barrantes, Francisco José
author_sort Barrantes, Francisco José
title The effects of cholesterol on the nicotinic acetylcholine receptor : an update
title_short The effects of cholesterol on the nicotinic acetylcholine receptor : an update
title_full The effects of cholesterol on the nicotinic acetylcholine receptor : an update
title_fullStr The effects of cholesterol on the nicotinic acetylcholine receptor : an update
title_full_unstemmed The effects of cholesterol on the nicotinic acetylcholine receptor : an update
title_sort effects of cholesterol on the nicotinic acetylcholine receptor : an update
publisher Nova
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8456
work_keys_str_mv AT barrantesfranciscojose theeffectsofcholesterolonthenicotinicacetylcholinereceptoranupdate
AT barrantesfranciscojose effectsofcholesterolonthenicotinicacetylcholinereceptoranupdate
bdutipo_str Repositorios
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