Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation

Abstract: The aims of the work were to improve our knowledge of the role of H4R in melanoma proliferation and assess in vivo the therapeutic efficacy of histamine, clozapine and JNJ28610244, an H4R agonist, in a preclinical metastatic model of melanoma. Additionally, we aimed to investigate the comb...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Massari, Noelia A., Nicoud, Melisa Beatriz, Sambuco, Lorena, Cricco, Graciela P., Martinel Lamas, Diego J., Herrero Ducloux, María V., Blanco, Horacio, Rivera, Elena S., Medina, Vanina Araceli
Formato: Artículo
Lenguaje:Inglés
Publicado: Impact Journals 2019
Materias:
ONCOLOGIA
MELANOMA
CANCER DE PIEL
HISTAMINA
TRATAMIENTO MEDICO
RADIACION IONIZANTE
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8369
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8369
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ONCOLOGIA
MELANOMA
CANCER DE PIEL
HISTAMINA
TRATAMIENTO MEDICO
RADIACION IONIZANTE
spellingShingle ONCOLOGIA
MELANOMA
CANCER DE PIEL
HISTAMINA
TRATAMIENTO MEDICO
RADIACION IONIZANTE
Massari, Noelia A.
Nicoud, Melisa Beatriz
Sambuco, Lorena
Cricco, Graciela P.
Martinel Lamas, Diego J.
Herrero Ducloux, María V.
Blanco, Horacio
Rivera, Elena S.
Medina, Vanina Araceli
Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation
topic_facet ONCOLOGIA
MELANOMA
CANCER DE PIEL
HISTAMINA
TRATAMIENTO MEDICO
RADIACION IONIZANTE
description Abstract: The aims of the work were to improve our knowledge of the role of H4R in melanoma proliferation and assess in vivo the therapeutic efficacy of histamine, clozapine and JNJ28610244, an H4R agonist, in a preclinical metastatic model of melanoma. Additionally, we aimed to investigate the combinatorial effect of histamine and gamma radiation on the radiobiological response of melanoma cells. Results indicate that 1205Lu metastatic melanoma cells express H4R and that histamine inhibits proliferation, in part through the stimulation of the H4R, and induces cell senescence and melanogenesis. Daily treatment with H4R agonists (1 mg/kg, sc) exhibited a significant in vivo antitumor effect and importantly, compounds reduced metastatic potential, particularly in the group treated with JNJ28610244, the H4R agonist with higher specificity. H4R is expressed in benign and malignant lesions of melanocytic lineage, highlighting the potential clinical use of histamine and H4R agonists. In addition, histamine increased radiosensitivity of melanoma cells in vitro and in vivo. We conclude that stimulation of H4R by specific ligands may represent a novel therapeutic strategy in those tumors that express this receptor. Furthermore, through increasing radiation-induced response, histamine could improve cancer radiotherapy for the treatment of melanoma.
format Artículo
author Massari, Noelia A.
Nicoud, Melisa Beatriz
Sambuco, Lorena
Cricco, Graciela P.
Martinel Lamas, Diego J.
Herrero Ducloux, María V.
Blanco, Horacio
Rivera, Elena S.
Medina, Vanina Araceli
author_facet Massari, Noelia A.
Nicoud, Melisa Beatriz
Sambuco, Lorena
Cricco, Graciela P.
Martinel Lamas, Diego J.
Herrero Ducloux, María V.
Blanco, Horacio
Rivera, Elena S.
Medina, Vanina Araceli
author_sort Massari, Noelia A.
title Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation
title_short Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation
title_full Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation
title_fullStr Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation
title_full_unstemmed Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation
title_sort histamine therapeutic efficacy in metastatic melanoma : role of histamine h4 receptor agonists and opportunity for combination with radiation
publisher Impact Journals
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8369
work_keys_str_mv AT massarinoeliaa histaminetherapeuticefficacyinmetastaticmelanomaroleofhistamineh4receptoragonistsandopportunityforcombinationwithradiation
AT nicoudmelisabeatriz histaminetherapeuticefficacyinmetastaticmelanomaroleofhistamineh4receptoragonistsandopportunityforcombinationwithradiation
AT sambucolorena histaminetherapeuticefficacyinmetastaticmelanomaroleofhistamineh4receptoragonistsandopportunityforcombinationwithradiation
AT criccogracielap histaminetherapeuticefficacyinmetastaticmelanomaroleofhistamineh4receptoragonistsandopportunityforcombinationwithradiation
AT martinellamasdiegoj histaminetherapeuticefficacyinmetastaticmelanomaroleofhistamineh4receptoragonistsandopportunityforcombinationwithradiation
AT herreroduclouxmariav histaminetherapeuticefficacyinmetastaticmelanomaroleofhistamineh4receptoragonistsandopportunityforcombinationwithradiation
AT blancohoracio histaminetherapeuticefficacyinmetastaticmelanomaroleofhistamineh4receptoragonistsandopportunityforcombinationwithradiation
AT riveraelenas histaminetherapeuticefficacyinmetastaticmelanomaroleofhistamineh4receptoragonistsandopportunityforcombinationwithradiation
AT medinavaninaaraceli histaminetherapeuticefficacyinmetastaticmelanomaroleofhistamineh4receptoragonistsandopportunityforcombinationwithradiation
bdutipo_str Repositorios
_version_ 1764820527976808449

Ejemplares similares