Association of Per3 length polymorphism with bipolar I disorder and schizophrenia

Abstract: Sleep–wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I)...

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Autores principales: Karthikeyan, Ramanujam, Marimuthu, Ganapathy, Ramasubramanian, Chellamuthu, Arunachal, Gautham, BaHammam, Ahmed S., Spence, David Warren, Cardinali, Daniel Pedro, Brown, Gregory M., Pandi Perumal, Seithikurippu R.
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: 2019
Materias:
POLIMORFISMO
TRASTORNO BIPOLAR
ESQUIZOFRENIA
RITMOS BIOLOGICOS
RITMO CIRCADIANO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1669
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1669
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic POLIMORFISMO
TRASTORNO BIPOLAR
ESQUIZOFRENIA
RITMOS BIOLOGICOS
RITMO CIRCADIANO
spellingShingle POLIMORFISMO
TRASTORNO BIPOLAR
ESQUIZOFRENIA
RITMOS BIOLOGICOS
RITMO CIRCADIANO
Karthikeyan, Ramanujam
Marimuthu, Ganapathy
Ramasubramanian, Chellamuthu
Arunachal, Gautham
BaHammam, Ahmed S.
Spence, David Warren
Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
topic_facet POLIMORFISMO
TRASTORNO BIPOLAR
ESQUIZOFRENIA
RITMOS BIOLOGICOS
RITMO CIRCADIANO
description Abstract: Sleep–wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. Methods: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. Results: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08–2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ2=4.634; P,0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. Conclusion: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group
format Artículo
author Karthikeyan, Ramanujam
Marimuthu, Ganapathy
Ramasubramanian, Chellamuthu
Arunachal, Gautham
BaHammam, Ahmed S.
Spence, David Warren
Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author_facet Karthikeyan, Ramanujam
Marimuthu, Ganapathy
Ramasubramanian, Chellamuthu
Arunachal, Gautham
BaHammam, Ahmed S.
Spence, David Warren
Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author_sort Karthikeyan, Ramanujam
title Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title_short Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title_full Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title_fullStr Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title_full_unstemmed Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title_sort association of per3 length polymorphism with bipolar i disorder and schizophrenia
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1669
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