Emerging drugs for autonomic dysfunction in Parkinson's disease

Abstract: Autonomic dysfunction, including orthostatic hypotension (OH), sialorrhea, sexual dysfunction, urinary dysfunction and constipation is a common feature of Parkinson’s disease (PD). Even though its treatment has been recognized as a major unmet need in PD, there is a paucity of clinical tri...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Pérez Lloret, Santiago, Rey, Verónica, Pavy-Le Traon, Anne, Rascol, Olivier
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Taylor and Francis 2019
Materias:
TOXINA BOTULIMICA
ESTREÑIMIENTO
DOMPERIDONA
DROXIDOPA
DISFUNCION ERECTIL
FLUDROCORTISONA
INCONTINENCIA
HIPOTENSION ORTOSTATICA
ENFERMEDAD DE PARKINSON
DISFUNCION URINARIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1667
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1667
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic TOXINA BOTULIMICA
ESTREÑIMIENTO
DOMPERIDONA
DROXIDOPA
DISFUNCION ERECTIL
FLUDROCORTISONA
INCONTINENCIA
HIPOTENSION ORTOSTATICA
ENFERMEDAD DE PARKINSON
DISFUNCION URINARIA
spellingShingle TOXINA BOTULIMICA
ESTREÑIMIENTO
DOMPERIDONA
DROXIDOPA
DISFUNCION ERECTIL
FLUDROCORTISONA
INCONTINENCIA
HIPOTENSION ORTOSTATICA
ENFERMEDAD DE PARKINSON
DISFUNCION URINARIA
Pérez Lloret, Santiago
Rey, Verónica
Pavy-Le Traon, Anne
Rascol, Olivier
Emerging drugs for autonomic dysfunction in Parkinson's disease
topic_facet TOXINA BOTULIMICA
ESTREÑIMIENTO
DOMPERIDONA
DROXIDOPA
DISFUNCION ERECTIL
FLUDROCORTISONA
INCONTINENCIA
HIPOTENSION ORTOSTATICA
ENFERMEDAD DE PARKINSON
DISFUNCION URINARIA
description Abstract: Autonomic dysfunction, including orthostatic hypotension (OH), sialorrhea, sexual dysfunction, urinary dysfunction and constipation is a common feature of Parkinson’s disease (PD). Even though its treatment has been recognized as a major unmet need in PD, there is a paucity of clinical trials to assess their treatment. Areas covered: Evidence about the efficacy and safety of available treatments for autonomic dysfunction is summarized. Potential targets for upcoming therapies are then discussed in light of what is currently known about the physiopathology of each disorder in PD. Proof-of-concept trials and circumstantial evidence about treatments for autonomic dysfunction as well as upcoming clinical trials are discussed. Finally, critical aspects of clinical trials design are considered. Expert opinion: Botulinum toxin (BTX) or glycopyrrolate might be used for sialorrhea whereas macrogol could be useful in constipation. There is preliminary evidence suggesting that fludrocortisone, domperidone, droxidopa or fipamezole may be effective for the treatment of OH. Tropicamide, clonidine or radiotherapy are under development for sialorrhea. Sildenafil may be effective for the treatment of erectile dysfunction; BTX or behavioral therapy for urinary incontinence and lubiprostone and probiotics for constipation. Sound clinical trials are needed in order to allow firm evidence-based recommendations about these treatments
format Artículo
author Pérez Lloret, Santiago
Rey, Verónica
Pavy-Le Traon, Anne
Rascol, Olivier
author_facet Pérez Lloret, Santiago
Rey, Verónica
Pavy-Le Traon, Anne
Rascol, Olivier
author_sort Pérez Lloret, Santiago
title Emerging drugs for autonomic dysfunction in Parkinson's disease
title_short Emerging drugs for autonomic dysfunction in Parkinson's disease
title_full Emerging drugs for autonomic dysfunction in Parkinson's disease
title_fullStr Emerging drugs for autonomic dysfunction in Parkinson's disease
title_full_unstemmed Emerging drugs for autonomic dysfunction in Parkinson's disease
title_sort emerging drugs for autonomic dysfunction in parkinson's disease
publisher Taylor and Francis
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1667
work_keys_str_mv AT perezlloretsantiago emergingdrugsforautonomicdysfunctioninparkinsonsdisease
AT reyveronica emergingdrugsforautonomicdysfunctioninparkinsonsdisease
AT pavyletraonanne emergingdrugsforautonomicdysfunctioninparkinsonsdisease
AT rascololivier emergingdrugsforautonomicdysfunctioninparkinsonsdisease
bdutipo_str Repositorios
_version_ 1764820525796818946

Ejemplares similares