Malaria : therapeutic implications of melatonin

Abstract: Malaria, which infects more than 300 million people annually, is a serious disease. Epidemiological surveys indicate that of those who are affected, malaria will claim the lives of more than one million individuals, mostly children. There is evidence that the synchronous maturation of Plas...

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Autores principales: Srinivasan, Venkataramanujan, Spence, David Warren, Moscovitch, Adam, Pandi Perumal, Seithikurippu R., Trakht, Ilya, Brown, Gregory M., Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Wiley 2019
Materias:
MALARIA
RECEPTORES DE MELATONINA
APOPTOSIS
ESTRES OXIDATIVO
APLICACIONES TERAPEUTICAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1664
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1664
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MALARIA
RECEPTORES DE MELATONINA
APOPTOSIS
ESTRES OXIDATIVO
APLICACIONES TERAPEUTICAS
spellingShingle MALARIA
RECEPTORES DE MELATONINA
APOPTOSIS
ESTRES OXIDATIVO
APLICACIONES TERAPEUTICAS
Srinivasan, Venkataramanujan
Spence, David Warren
Moscovitch, Adam
Pandi Perumal, Seithikurippu R.
Trakht, Ilya
Brown, Gregory M.
Cardinali, Daniel Pedro
Malaria : therapeutic implications of melatonin
topic_facet MALARIA
RECEPTORES DE MELATONINA
APOPTOSIS
ESTRES OXIDATIVO
APLICACIONES TERAPEUTICAS
description Abstract: Malaria, which infects more than 300 million people annually, is a serious disease. Epidemiological surveys indicate that of those who are affected, malaria will claim the lives of more than one million individuals, mostly children. There is evidence that the synchronous maturation of Plasmodium falciparum, the parasite that causes a severe form of malaria in humans and P. chabaudi, responsible for rodent malaria, could be linked to circadian changes in melatonin concentration. In vitro melatonin stimulates the growth and development of P. falciparum through the activation of specific melatonin receptors coupled to phospholipase-C activation and the concomitant increase of intracellular Ca2+. The Ca2+ signaling pathway is important to stimulate parasite transition from the trophozoite to the schizont stage, the final stage of intraerythrocytic cycle, thus promoting the rise of parasitemia. Either pinealectomy or the administration of the melatonin receptor blocking agent luzindole desynchronizes the parasitic cell cycle. Therefore the use of melatonin antagonists could be a novel therapeutic approach for controlling the disease. On the other hand, the complexity of melatonin’s action in malaria is underscored by the demonstration that treatment with high doses of melatonin is actually beneficial for inhibiting apoptosis and liver damage resulting from the oxidative stress in malaria. The possibility that the coordinated administration of melatonin antagonists (to impair the melatonin signal that synchronizes P. falciparum) and of melatonin in doses high enough to decrease oxidative damage could be a novel approach in malaria treatment is discussed.
format Artículo
author Srinivasan, Venkataramanujan
Spence, David Warren
Moscovitch, Adam
Pandi Perumal, Seithikurippu R.
Trakht, Ilya
Brown, Gregory M.
Cardinali, Daniel Pedro
author_facet Srinivasan, Venkataramanujan
Spence, David Warren
Moscovitch, Adam
Pandi Perumal, Seithikurippu R.
Trakht, Ilya
Brown, Gregory M.
Cardinali, Daniel Pedro
author_sort Srinivasan, Venkataramanujan
title Malaria : therapeutic implications of melatonin
title_short Malaria : therapeutic implications of melatonin
title_full Malaria : therapeutic implications of melatonin
title_fullStr Malaria : therapeutic implications of melatonin
title_full_unstemmed Malaria : therapeutic implications of melatonin
title_sort malaria : therapeutic implications of melatonin
publisher Wiley
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1664
work_keys_str_mv AT srinivasanvenkataramanujan malariatherapeuticimplicationsofmelatonin
AT spencedavidwarren malariatherapeuticimplicationsofmelatonin
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AT trakhtilya malariatherapeuticimplicationsofmelatonin
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